中央研究院原子與分子科學研究所 - 首頁 (Institute of Atomic and Molecular Sciences, Academia Sinica)

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林靖衛博士

Cytometry in the Short-Wave Infrared

ACS Nano 18, 18534–18547 (2024).

Cytometry plays a crucial role in characterizing cell properties, but its restricted optical window (400-850 nm) limits the number of stained fluorophores that can be detected simultaneously and hampers the study and utilization of short-wave infrared (SWIR; 900-1,700 nm) fluorophores in cells. Here we introduce two SWIR-based methods to address these limitations: SWIR flow cytometry and SWIR image cytometry. We develop a quantification protocol for deducing cellular fluorophore mass. Both systems achieve a limit of detection of ~0.1 fg cell⁻¹ within a 30-min experimental timeframe, using individualized, high-purity (6,5) single-wall carbon nanotubes as a model fluorophore and macrophage-like RAW264.7 as a model cell line. This high-sensitivity feature reveals that low-dose (6,5) serves as an antioxidant, and cell morphology a ...
羅佩凌博士

Accurate kinetic studies of OH + HO₂ radical–radical reaction through direct measurement of precursor and radical concentrations with high-resolution time-resolved dual-comb spectroscopy

J. Phys. Chem. Lett.,15, 3733–3739 (2024)

The radical–radical reaction between OH and HO₂ has been considered for a long time as an important reaction in tropospheric photochemistry and combustion chemistry. However, a significant discrepancy of an order of magnitude for rate coefficients of this reaction is found between two recent experiments. Herein, we investigate the reaction OH + HO₂ via direct spectral quantification of both the precursor (H₂O₂) and free radicals (OH and HO₂) upon the 248 nm photolysis of H₂O₂ using infrared two-color time-resolved dual-comb spectroscopy. With quantitative and kinetic analysis of concentration profiles of both OH and HO₂ at varied conditions, the rate coefficient k_OH+HO2 is determined to be (1.10 ± 0.12) &time ...
任祥華博士

Generating scalable graph states in an atom-nanophotonic interface

Quantum Sci. Tech. 9, 025020 (2024).

Scalable graph states are essential for measurement-based quantum computation and many entanglement-assisted applications in quantum technologies. Generation of these multipartite entangled states requires a controllable and efficient quantum device with delicate design of generation protocol. Here we propose to prepare high-fidelity and scalable graph states in one and two dimensions, which can be tailored in an atom-nanophotonic cavity via state carving technique. We propose a systematic protocol to carve out unwanted state components, which facilitates scalable graph states generations via adiabatic transport of a definite number of atoms in optical tweezers. An analysis of state fidelity is also presented, and the state preparation probability can be optimized via multiqubit state carvings and sequential single-photon probes. Our results showca ...
謝佳龍博士

Point Spread Function Engineering for Spiral Phase Interferometric Scattering Microscopy Enables Robust 3D Single-Particle Tracking and Characterization

ACS Photonics 11(12), 5239–5250 (2024)

Interferometric scattering (iSCAT) microscopy is currently among the most powerful techniques available for achieving high-sensitivity single-particle localization. This capability is realized through homodyne detection, where interference with a reference wave offers the promise of exceptionally precise three-dimensional (3D) localization. However, the practical application of iSCAT to 3D tracking has been hampered by rapid oscillations in the signal-to-noise ratio (SNR) as particles move along the axial direction. In this study, we introduce a novel strategy based on back pupil plane engineering, wherein a spiral phase mask is used to redistribute the phase of the scattered field of the particle uniformly across phase space, thus ensuring consistent SNR as the particle moves throughout the focal volume. Our findings demonstrate that this modified ...
羅佩凌博士

Direct gas-phase formation of formic acid through reaction of Criegee intermediates with formaldehyde

Communications Chemistry, 6, 130 (2023)

Ozonolysis of isoprene is considered to be an important source of formic acid (HCOOH), but its underlying reaction mechanisms related to HCOOH formation are poorly understood. Here, we report the kinetic and product studies of the reaction between the simplest Criegee intermediate (CH₂OO) and formaldehyde (HCHO), both of which are the primary products formed in ozonolysis of isoprene. By utilizing time-resolved infrared laser spectrometry with the multifunctional dual-comb spectrometers, the rate coefficient k_CH2OO+HCHO is determined to be (4.11 ± 0.25) × 10⁻¹² cm³ molecule⁻¹ s⁻¹ at 296 K and a negative temperature dependence of the rate coefficient is observed and described by an Arrheni ...
張煥正博士

Imaging Extreme Ultraviolet Radiation Using Nanodiamonds with Nitrogen-Vacancy Centers

Nano Lett. 23, 9811–9816 (2023).

Extreme ultraviolet (EUV) radiation with wavelengths of 10 – 121 nm has drawn considerable attention recently for its use in photolithography to fabricate nanoelectronic chips. This study demonstrates, for the first time, fluorescent nanodiamonds (FNDs) with nitrogen-vacancy (NV) centers as scintillators to image and characterize EUV radiations. The FNDs employed are ~100 nm in size; they form a uniform and stable thin film on an indium tin oxide-coated slide by electrospray deposition. The film is non-hygroscopic, photostable, and can emit bright red fluorescence from NV⁰ centers when excited by EUV light. An FND-based imaging device has been developed and applied for beam diagnostics of 50 nm and 13.5 nm synchrotron radiations, achieving a spatial resolution of 30 μm using a film of ~1 μm thickness.& ...
許良彥博士

Chemistry Meets Plasmon Polaritons and Cavity Photons: A Perspective from Macroscopic Quantum Electrodynamics

J. Phys. Chem. Lett., 16, 1604−1619 (2025).

The interaction between light and molecules under quantum electrodynamics (QED) has long been less emphasized in physical chemistry, as semiclassical theories have dominated due to their relative simplicity. Recent experimental advances in polariton chemistry highlight the need for a theoretical framework that transcends traditional cavity QED and molecular QED models. Macroscopic QED is presented as a unified framework that seamlessly incorporates infinite photonic modes and dielectric environments, enabling applications to systems involving plasmon polaritons and cavity photons. This Perspective demonstrates the applicability of macroscopic QED to chemical phenomena through breakthroughs in molecular fluorescence, resonance energy transfer, and electron transfer. The macroscopic QED framework not only resolves the limitations of classical theorie ...
謝雅萍博士

Tungsten Nitride (W5N6): An Ultraresilient 2D Semimetal

Nano Letters 24, 1, 67 (2024)

Two-dimensional transition metal nitrides offer intriguing possibilities for achieving novel electronic and mechanical functionality owing to their distinctive and tunable bonding characteristics compared to other 2D materials. We demonstrate here the enabling effects of strong bonding on the morphology and functionality of 2D tungsten nitrides. The employed bottom-up synthesis experienced a unique substrate stabilization effect beyond van-der-Waals epitaxy that favored W5N6 over lower metal nitrides. Comprehensive structural and electronic characterization reveals that monolayer W5N6 can be synthesized at large scale and shows semimetallic behavior with an intriguing indirect band structure. Moreover, the material exhibits exceptional resilience against mechanical damage and chemical reactions. Leveraging these electronic properties and ...
任祥華博士

Accelerating multipartite entanglement generation in non-Hermitian superconducting qubits

Quantum Sci. Technol. 10 025021 (2025).

Open quantum systems are susceptible to losses in information, energy, and particles due to their surrounding environment. One novel strategy to mitigate these losses is to transform them into advantages for quantum technologies through tailored non-Hermitian quantum systems. In this work, we theoretically propose a fast generation of multipartite entanglement in non-Hermitian qubits. Our findings reveal that weakly coupled non-Hermitian qubits can accelerate multiparty entanglement generation by thousands of times compared to Hermitian qubits, in particular when approaching the 2^n-th order exceptional points of n qubits in the PT-symmetric regime. Furthermore, we show that Hermitian qubits can generate GHZ states with a high fidelity more than 0.9995 in a timescale comparable to that of non-Hermitian qubits, but at the expense of intense driving ...
謝雅萍博士

Enhancing the Electrochemical Activity of 2D Materials Edges through Oriented Electric Fields

ACS Nano 18, 19828 (2024)

The edges of 2D materials have emerged as promising electrochemical catalyst systems, yet their performance still lags behind that of noble metals. Here, we demonstrate the potential of oriented electric fields (OEFs) to enhance the electrochemical activity of 2D materials edges. By atomically engineering the edge of a fluorographene/graphene/MoS2 heterojunction nanoribbon, strong and localized OEFs were realized as confirmed by simulations and spatially resolved spectroscopy. The observed fringing OEF results in an enhancement of the heterogeneous charge transfer rate between the edge and the electrolyte by 2 orders of magnitude according to impedance spectroscopy. Ab initio calculations indicate a field-induced decrease in the reactant adsorption energy as the origin of this improvement. We apply the OEF-enhanced edge reactivity to hydrogen ...
許良彥博士

Non-Adiabatic Quantum Electrodynamic Effects on Electron–Nucleus–Photon Systems: Single Photonic Mode vs Infinite Photonic Modes [Feature Article]

J. Chem. Phys. 162, 034107 (2025).

The quantum-electrodynamic non-adiabatic emission (QED-NAE) is a type of radiatively assisted vibronic de-excitation due to electromagnetic vacuum fluctuations on non-adiabatic processes. Building on our previous work [Tsai et al., J. Phys. Chem. Lett. 14, 5924 (2023)], we extend the theory of the QED-NAE rate from a single cavity photonic mode to infinite photonic modes and calculate the QED-NAE rates of 9-cyanoanthracene at the first-principles level. To avoid the confusion, the quantum electrodynamic internal conversion process is renamed as “QED-NAE” in our present work. According to our theory, we identify three key factors influencing the QED-NAE processes: light–matter coupling strength (mode volume), mass-weighted orientation factor, and photonic density of states. The mode volume is the primary factor causing rate differe ...
賴品光博士

Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers in vivo

Advanced Materials. https://doi.org/10.1002/adma.202208966 (2023).

Our latest publication employed PalmGRET, a bioluminescence-resonance-energy-transfer (BRET)-based EV reporter, to discover an abundant release of big EVs (bEVs; >200 nm) by aggressive breast cancers when compared to epithelial and less malignant cells. bEVs have been largely overshadowed by small EVs (sEVs; <200 nm) in EV research in the past decades. This is the first study to accurately detect and systematically compare biophysical property and in vivo profiles of breast cancer bEVs and sEVs. This is followed by the identification of EV surface oncoproteins, and their role in modulating organotropism and tumorigenic potential of the bEVs and sEVs. Our landmark findings impart a broad and deep reference for upcoming EV studies, with an emphasis on EV engineering for diagnosis and therapeutic applications.

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演講資訊

Mar
27
2025

Laboratory Astrophysics and Astrochemistry

陳俞融主任, 國立中央大學物理學系

2025-03-27 下午 03:30 浦大邦紀念講堂

Apr
10
2025

Interference-caged quantum many-body scars: the Fock space topological localization and interference zeros

黃一平助理教授, 國立清華大學物理學系

2025-04-10 下午 03:30 浦大邦紀念講堂

Apr
24
2025

Quantum Transport Simulations for Twisted Bilayer MoS₂ and Spin-Orbit-Proximitized Graphene

劉明豪教授, 國立成功大學物理學系

2025-04-24 下午 03:30 浦大邦紀念講堂

May
08
2025

Toward a Systemic in vitro Model: Microfluidic Cell Culture

董奕鍾研究員, 本院應用科學研究中心

2025-05-08 下午 03:30 浦大邦紀念講堂

May
15
2025

Ultrafast Dynamics and Orbital-Dependent Charge Density Wave Mechanisms in 1T-TiSe₂

林秉慧助研究員, 國家同步輻射研究中心

2025-05-15 下午 03:30 浦大邦紀念講堂

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活動資訊

Special Symposium on Interferometric Scattering Microscopy (iSCAT 2025)

相關連結

浦大邦紀念講堂
2025-04-17 上午 09:00 ~ 下午 06:00

We are delighted to invite you to the Special Symposium on Interferometric Scattering Microscopy 2025 (iSCAT 2025), which will be held on April 17, 2025, in Taiwan. iSCAT microscopy, celebrated for its extraordinary sensitivity and speed in detecting light scattering from nanoscale objects, continues to break new ground in studying biological systems and precisely characterizing nanoparticles.

iSCAT 2025 will feature invited talks by leading research groups who will present their latest advancements in iSCAT techniques and their diverse applications. This symposium will serve as a dynamic forum for experts, researchers, and students engaged in discussing progress in iSCAT and related scattering-based optical methods or their utilization in exploring biological and material sciences. This event promises to foster collaboration, inspire innovation, and promote knowledge exchange.

Registration deadline: March 23, 2025

Celebration of IAMS 30th anniversary Workshop on Carbohydrate Research From Quantum chemistry and analytical chemistry to Glycobiology

相關連結

浦大邦紀念講堂
2025-04-28 上午 09:00 ~ 2025-04-30 下午 05:00

As part of the 30th anniversary celebrations of the Institute of Atomic and Molecular Sciences (IAMS), we are pleased to host a Workshop on Carbohydrate Research. This workshop will bring together researchers from diverse disciplines—including quantum chemistry, analytical chemistry, and glycobiology—to discuss the latest advancements in Carbohydrate Research. Our goal is to provide a platform for both domestic and international scientists to share their recent findings, exchange ideas, and establish potential collaborations. By fostering interactions between experimental and theoretical researchers, we aim to explore challenges across different aspects of Carbohydrate Research and uncover new opportunities for interdisciplinary cooperation. We look forward to engaging discussions and valuable insights that will shape the future of this exciting research field.

中央研究院-全院計畫

常用連結

國際研究生學程(TIGP)

IAMS International Internship Program

學生專區

原分所暑期研究

科學家在玩什麼