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重要研究成果

汪治平 博士
(2020)
Zan Nie, Chih-Hao Pai, Jie Zhang, Xiaonan Ning, Jianfei Hua, Yunxiao He, Yipeng Wu, Qianqian Su, Shuang Liu, Yue Ma, Zhi Cheng, Wei Lu1, Hsu-Hsin Chu, Jyhpyng Wang, Chaojie Zhang, Warren B. Mori, and Chan Joshi
Nature Communication 11, 2787 (2020)
Availability of relativistically intense, single-cycle, tunable infrared sources will open up newareas of relativistic nonlinear optics of plasmas, impulse IR spectroscopy and pump-probeexperiments in the molecular fingerprint region. However, generation of such pulses is still achallenge by current methods. Recently, it has been proposed that time dependent refractiveindex associated with laser-produced nonlinear wakes in a suitably designed plasma densitystructure rapidly frequency down-converts photons. The longest wavelength photons slipbackwards relative to the evolving laser pulse to form a single-cycle pulse within the nearlyevacuated wake cavity. This process is called photon deceleration. Here, we demonstrate thisscheme for generating high-power (~100 GW), near single-cycle, wavelength tunable(3–20 μm), infrared pulses using an 810 nm drive laser by tuning the density profile of theplasma. We also demonstrate that these pulses can be used to in-situ probe the transient andnonlinear wakes themselves.
謝雅萍 博士
(2020)
Heming Yao, Ya-Ping Hsieh, Jing Kong and Mario Hofmann
Nature Materials, DOI:10.1038/s41563-020-0664-1 (2020).
本研究題目Modelling electrical conduction in nanostructure assemblies through complex networks的代表性圖片
Carrier transport processes in assemblies of nanostructures rely on morphology-dependent and hierarchical conduction mechanisms, whose complexity cannot be captured by current modelling approaches. Here we apply the concept of complex networks to modelling carrier conduction in such systems. The approach permits assignment of arbitrary connectivity and connection strength between assembly constituents and is thus ideal for nanostructured films, composites and other geometries. Modelling of simplified rod-like nanostructures is consistent with analytical solutions, whereas results for more realistic nanostructure assemblies agree with experimental data and reveal conduction behaviour not captured by previous models. Fitting of ensemble measurements also allows the conduction properties of individual constituents to be extracted, which are subsequently used to guide the realization of transparent electrodes with improved performance. A global optimization process was employed to identify geometries and properties with high potential for transparent conductors. Our intuitive discretization approach, combined with a simple solver tool, allows researchers with little computational experience to carry out realistic simulations.
廖仲麒 博士
(2020)
eLife 9, e53580 (2020).
本研究題目Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages的代表性圖片
Subdistal appendages (sDAPs) are centriolar elements observed proximal to the distal appendages (DAPs) in vertebrates. Despite their obvious presence, structural and functional understanding of sDAPs remains elusive. Here, by combining super-resolved localization analysis and CRISPR-Cas9 genetic perturbation, we find that, although DAPs and sDAPs are primarily responsible for distinct functions in ciliogenesis and microtubule anchoring respectively, the presence of one element actually affects the positioning of the other. Specifically, we find dual layers of both ODF2 and CEP89, where their localizations are differentially regulated by DAP and sDAP integrity. DAP depletion relaxes longitudinal occupancy of sDAP protein ninein to cover the DAP region, implying a role of DAPs in sDAP positioning. Removing sDAPs alter the distal border of centrosomal γ-tubulins, illustrating a new role of sDAPs. Together, our results provide an architectural framework of sDAPs to shed light on functional understanding, surprisingly revealing the coupling between DAPs and sDAPs.
謝佳龍 博士
(2020)
Yi-Hung Liao, Chih-Hsiang Lin, Ching-Ya Cheng, Wai Cheng Wong, Jz-Yuan Juo, Chia-Lung Hsieh*
ACS Nano 13(10), 10918-10928 (2019)
本研究題目Monovalent and Oriented Labeling of Gold Nanoprobes for the High-Resolution Tracking of a Single-Membrane Molecule的代表性圖片
Single-molecule tracking is a powerful method to study molecular dynamics in living systems including biological membranes. High-resolution single-molecule tracking requires a bright and stable signal, which has typically been facilitated by nanoparticles due to their superb optical properties. However, there are concerns about using a nanoparticle to label a single molecule because of its relatively large size and the possibility of cross-linking multiple target molecules, both of which could affect the original molecular dynamics. In this work, using various labeling schemes, we investigate the effects using nanoparticles to measure the diffusion of single-membrane molecules. We demonstrate a simple and robust strategy for the monovalent and oriented labeling of a single lipid molecule with a AuNP by using naturally dimeric rhizavidin (rAv) as a bridge, thus connecting the biotinylated nanoparticle surface and biotinylated target molecule. The rAv–AuNP conjugate shows fast and free diffusion in supported lipid bilayers (2–3 μm2/s for rAv–AuNP sizes of 10–40 nm), which is comparable to the diffusion of dye-labeled lipids, indicating that the adverse size and cross-linking effects are successfully avoided. Our work shows that the measured diffusion of the membrane molecule is highly sensitive to the molecular design of the cross-linker for labeling. The demonstrated approach of monovalent and oriented AuNP labeling provides the opportunity to study single-molecule membrane dynamics at much higher spatiotemporal resolutions and, most importantly, without labeling artifacts.This work is selected as 2019 Significant Research Achievement of Academia Sinica and reported by ACS Nano Perspective (Yanqi Yu, Miao Li, Yan Yu. Tracking Single Molecules in Biomembranes: Is Seeing Always Believing?. ACS Nano 2019, 13 (10) , 10860-10868.)
張煥正 博士
(2020)

Hsiao-Chi Lu,†,* Jen-Iu Lo, Yu-Chain Peng, Sheng-Lung Chou, Bing-Ming Cheng,†,* and Huan-Cheng Chang‡,*

National Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300, Taiwan
Institute of Atomic and Molecular Sciences, Academia Sinica, 1 Section 4, Roosevelt Road, Taipei 106, Taiwan

ACS Appl. Mater. Interfaces 12, 3847−3853 (2020).
本研究題目Nitrogen-Vacancy Centers in Diamond for High-Performance Detection of Vacuum Ultraviolet, Extreme Ultraviolet, and X‑rays的代表性圖片
Fluorescent nanodiamond (FND) containing nitrogen-vacancy (NV) centers as built-in fluorophores exhibits a nearly constant emission profile over 550 – 750 nm upon excitation by vacuum-ultraviolet (VUV), extreme ultraviolet (EUV), and X- radiations from a synchrotron source over the energy (wavelength) range of 6.2 – 1450 eV (0.86 – 200 nm).  The photoluminescence (PL) quantum yield of FND increases steadily with the increasing excitation energy, attaining a value as great as 1700% at 700 eV (1.77 nm).  Notably, the yield curve is continuous, having no gap in the VUV to X-ray region.  In addition, no significant PL intensity decreases were observed for hours.  Applying the FND sensor to measure the absorption cross sections of gaseous O2 over 110 – 200 nm and comparing the measurements with the sodium-salicylate scintillator, we obtained results in agreement with each other within 5%.  The superb photostability and broad applicability of FND offer a promising solution for the long-standing problem of lacking a robust and reliable detector for VUV, EUV, and X- radiations.
 
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