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  • 謝佳龍 博士
    ACS Nano, 11(3), 2575–2585 (2017).
    Viral infection starts with a virus particle landing on a cell surface followed by penetration of the plasma membrane. Due to the difficulty of measuring the rapid motion of small-sized virus particles on the membrane, little is known about how a virus particle reaches an endocytic site after landing at a random location. Here, we use coherent brightfield (COBRI) microscopy to investigate early-stage viral infection with ultrahigh spatiotemporal resolution. By detecting intrinsic scattered light via imaging-based interferometry, COBRI microscopy allows us to track the motion of a single vaccinia virus particle with nanometer spatial precision (< 3 nm) in 3D and microsecond temporal resolution (up to 100,000 frames per second). We explore the possibility of differentiating the virus signal from cell background based on their distinct spatial and  ...
  • 張煥正 博士
    Angew. Chem. Int. Ed. 56, 3025–3030 (2017).
    Much of the current understanding of thermal effects in biological systems is based on macroscopic measurements.  There is little knowledge about the local thermostability or heat tolerance of subcellular components at the nanoscale.  Herein, we show that gold nanorod-fluorescent nanodiamond (GNR-FND) hybrids are useful as a combined nanoheater-nanothermometer in living cells.  With the use of a 594 nm laser for both heating and probing, we measured the temperature changes by recording the spectral shifts of the zero-phonon lines of negatively charged nitrogen-vacancy centers in FNDs.  The technique allows us to determine the rupture temperatures of individual membrane nanotubes in human embryonic kidney cells, as well as to generate high temperature gradients on the cell membrane for photoporation and optically controlled hyper ...
  • 楊大衍 博士
    Scientific Reports 7, 39792 (2017).
    Proteins are of interest in nano-bio electronic devices due to their versatile structures, exquisite functionality and specificity. However, quantum transport measurements produce conflicting results due to technical limitations whereby it is difficult to precisely determine molecular orientation, the nature of the moieties, the presence of the surroundings and the temperature; in such circumstances a better understanding of the protein electron transfer (ET) pathway and the mechanism remains a considerable challenge. Here, we report an approach to mechanically drive polypeptide flip-flop motion to achieve a logic gate with ON and OFF states during protein ET. We have calculated the transmission spectra of the peptide-based molecular junctions and observed the hallmarks of electrical current and conductance. The results indicate that peptide ET fol ...
  • 劉國平 博士
    Nature Chemistry, 9, 1175-1180 (2017).
    The transition state, which gates and modulates the reactive flux, serves as the central concept in our understanding of activated reactions. The barrier height of the transition state can be estimated from the activation energy taken from thermal kinetics data or from the energetic threshold in the measured excitation function (the dependence of reaction cross sections on initial collision energies). However, another critical and equally important property, the angle-dependent barrier to reaction, has not yet been amenable to experimental determination until now. Here, using the benchmark reaction of Cl + CHD3(v1 = 1) as an example, we show how to map this anisotropic property of the transition state as a function of collision energy from the preferred reactant bond alignment of the backward-scattered products ‒ the imprints of small  ...
  • 曾文碧 博士
    Chem. Eur. J., 23, 13669-13675 (2017).
    High-resolution mass-analyzed threshold ionization (MATI) spectra of (h6-Ph2)2Cr and (h6-Ph2)(h6-PhMe)Cr demonstrate that the Ph groups work as electron donors, decreasing the ionization energy of the gas-phase bisarene complexes. In contrast to electrochemical data, a close similarity of the Ph and Me group effects on the oxidation of free sandwich molecules has been revealed. However, DFT calculations testify for the opposite shifts of the electron density caused by the Me and Ph substituents in the neutral complexes, the latter behaving as an electron-accepting fragment. On the contrary, in the bisarene cations, the Ph group becomes a stronger donor than methyl. This change provides the similar substituent effects observed with the MATI experiment. On the other hand, the well-documented opposite influence of the Me and Ph fragments on the redox  ...
  • 許良彥 博士
    Nano Lett. (DOI: 10.1021/acs.nanolett.8b01838, 2018)
    In this study, we explore photoinduced electron transport through a molecule weakly coupled to two electrodes by combining first-principles quantum chemistry calculations with a Pauli master equation approach that accounts for many-electron states. In the incoherent limit, we demonstrate that energy-level alignment of triplet and charged states plays a crucial role, even when the rate of intersystem crossing is much smaller than the rate of fluorescence. Furthermore, the field intensity dependence and an upper bound to the photoinduced electric current can be analytically derived in our model. Under an optical field, the conductance spectra (charge stability diagrams) exhibit unusual Coulomb diamonds, which are associated with molecular excited states, and their widths can be expressed in terms of energies of the molecular electronic states. This s ...
  • 陳應誠 博士
    Phys. Rev. Lett. 120, 183602 (2018).
    Quantum memory is a device that can store and then retrieve a quantum state on demand. It is an important building block in long-distance quantum communication. To outperform the direct transmission of photons with quantum repeaters, it is crucial to develop quantum memories with high fidelity, high efficiency and a long storage time. We achieved a storage efficiency of 92.0 % for a coherent optical memory based on the electromagnetically induced transparency scheme in optically dense cold atomic media. We also obtain a useful time-bandwidth product of 1200, considering only storage where the retrieval efficiency remains above 50 %. Both are the best record to date in all kinds of the schemes for the realization of optical memory. Our work significantly advances the pursuit of a high-performance optical memory and should have important applications ...
  • 廖仲麒 博士
    Nature Communications, 9, 2023 (2018).
    Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather than pinwheels, intact DAPs exhibit a cone-shaped architecture with components filling the space between each pinwheel blade, a new structural element we term the distal appendage matrix (DAM). Specifically, CEP83, CEP89, SCLT1, and CEP164 form the backbone of pinwheel blades, with CEP83 confined at the root and CEP164 extending to the tip near the membrane-docking site. By contrast, FBF1 marks the distal end of the DAM near the ciliary membrane. Strikingly, unlike CEP164, which is essential for ciliogenesis, FBF1 is required for ciliary ...
  • 余慈顏 博士
    Scientific Reports, 8, 13501 (2018).
    Incorporating membrane proteins into membrane mimicking systems is an essential process for biophysical studies and structure determination. Monodisperse lipid nanodiscs have been found to be a suitable tool, as they provide a near-native lipid bilayer environment. Recently, a covalently circularized nanodisc (cND) assembled with a membrane scaffold protein (MSP) in circular form, instead of conventional linear form, has emerged. Covalently circularized nanodiscs have been shown to have improved stability, however the optimal strategies for the incorporation of membrane proteins, as well as the physicochemical properties of the membrane protein embedded in the cND, have not been studied. Bacteriorhodopsin (bR) is a seven-transmembrane helix (7TM) membrane protein, and it forms a two dimensional crystal consisting of trimeric bR on the purple membra ...
  • 陳貴賢 博士
    NATURE COMMUNICATIONS (DOI: 10.1038/s41467-017-02547-4, 2018)
    Carbon-doped SnS2 (SnS2-C) metal dichalcogenide nanostructure has been synthesized using a hydrothermal technique, which exhibits a highly active and selective photocatalytic conversion of CO2 to hydrocarbons under visible-light, attaining a photochemical quantum efficiency of above 0.7%. The SnS2 -C photocatalyst represents an important contribution towards high quantum efficiency artificial photosynthesis based on gas phase photocatalytic CO2 reduction under visible light.
  • 高橋開人 博士
    Physical Chemistry Chemical Physics, 20, 20217-20227 (2018).
    Criegee intermediates (CIs), formed in the reactions of unsaturated hydrocarbons with ozone, are very reactive carbonyl oxides and have recently been suggested as important oxidants in the atmosphere. In this work, we studied the substituent effect on the water monomer and dimer reaction with CIs which include up to three carbon atoms at the QCISD(T)/CBS//B3LYP/6-311+G(2d,2p) level. Our calculation showed that for saturated CIs with a hydrogen atom on the same side as the terminal oxygen atom, the reaction with water vapor would likely dominate the removal processes of these CIs in the atmosphere. On the other hand, for unsaturated CIs, the reactivity toward water vapor decreases compared to the saturated species allowing them to survive in humid atmospheric environments. We also evaluated the kinetic isotope effect in the reaction between CI and w ...

最新消息

演講資訊

Sep
27
2018
Molecular exchange between Helicobacter pylori and gastric epithelium: A chemist's view
林俊宏研究員, 本院生物化學研究所
2018-09-27 下午 03:30  浦大邦紀念講堂
Oct
04
2018
Tuning the Interface of Electrocatalysts
鄭耿鋒教授, 上海復旦大學化學系及先進材料實驗室
2018-10-04 下午 03:30  浦大邦紀念講堂
Oct
11
2018
In silico investigation of molecular mechanisms of biomolecules
張書瑋助理教授, 國立臺灣大學土木工程系
2018-10-11 下午 03:30  浦大邦紀念講堂
Oct
18
2018
(To be announced)
朱志教授, 廈門大學化學化工學院
2018-10-18 下午 03:30  浦大邦紀念講堂
Oct
25
2018
Superresolution microscopy and microscopy-enabled proteomics for biological applications
廖仲麒博士, 本所副研究員
2018-10-25 下午 03:30  浦大邦紀念講堂

活動資訊

The 3rd Asian Conference on Thermoelectrics (ACT3) & The 5th Micro & Nanoscale Heat Transfer and Energy Workshop (MNHTE2018)
浦大邦紀念講堂 & 松柏講堂
2018-10-07 下午 01:50 ~ 2018-10-09 下午 06:30
We welcome you to the 3rd Asia Conference on Thermoelectrics (3rd ACT) and the 5th Micro & Nanoscale Heat Transfer and Energy Workshop (MNHTE2018), holding together at Institute of Atomic and Molecular Science of Academia Sinica, in the campus of National Taiwan University, Taipei, Taiwan. The 3rd ACT, following its predecessors in Wuhan (China) and Kyoto (Japan), will provide a platform for researchers interested in various topics of thermoelectric materials to exchange their latest works. We especially welcome participants from our neighborhoods to visit us, find more common interests, and establish more collaborations in the future. The MNHTE2018 will cover frontier topics of heat/energy transfer phenomena of novel materials by advanced tools or novel methods. The workshop aims at bringing together researchers in Taiwan and sharing their works with international scholars. Because heat transfer phenomena are of fundamental importance in improving thermoelectric properties, we believe that it will be highly beneficial to bring researchers from the two conferences together. The 3rd ACT and MNHTE2018 will have tutorials on Oct 7, followed by two-days conferences on Oct 8~9, at the campus of National Taiwan University. The conference is organized by Academia Sinica and National Taiwan University. We look forward to your visit and your enthusiastic participation.
前瞻顯微技術實作研習營
中央研究院跨領域科技研究大樓
2018-10-17 上午 09:00 ~ 2018-10-21 下午 08:00
為提升國內生物研究的顯微技術水準,使更多的生物實驗室在顯微造影技術能夠達到大多數國際一流實驗室的能力,中央研究院特別推出「前瞻顯微技術實作研習營」,邀請國內外影像技術的專家開設一為期五天的活動。
中央研究院90週年慶科學及人文前瞻論壇
浦大邦紀念講堂
2018-11-23 上午 09:30 ~ 下午 05:00
今年(2018)是中央研究院90周年慶,院方舉辦許多慶祝活動,其中科學及人文前瞻論壇是由院內多個研究所針對不同主題邀請國內外傑出年輕學者舉辦的一系列論壇活動,希望能放眼本院未來10年的學術發展,為本院人文與科學典範的傳承,標誌出承先啟後的格局與意義。鑒於量子科學與技術領域近年來的蓬勃發展,原分所很榮幸邀請到在量子氣體研究卓越的金政教授,以及在量子資訊與量子計算研究卓越的謝明修教授,除講述他們個人的精彩研究外,也藉由他們在相關領域所具備的宏觀學術視野,展望該領域在未來十年的發展。在他們的演講後,我們將舉辦一場座談會,歡迎對這些主題有興趣的學者及學生參與,分享與交流對這個領域各種不同面向的看法與展望。
10th Asian Photochemistry Conference
公務人力發展中心福華國際文教會館
2018-12-16 下午 06:00 ~ 2018-12-20 下午 04:00
Established in 1996, the Asian Photochemistry Conference (APC) aims to provide scientists a major forum to discuss their latest developments in fundamental and applied photochemistry and related research areas. The APC has been successfully held in various countries including Australia, China, India, Japan, Korea, New Zealand, Singapore, and Taiwan. The 10th Asian Photochemistry Conference (APC 2018) is organized by Academia Sinica and National Taiwan University. The Organizing Committee welcomes you to participate in APC 2018 to be held in the Howard Civil Service International House, Taipei, Taiwan on 16-20 December, 2018.
 
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最後更新於 2018-09-26 13:27:20
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