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  • 林志民 博士
    Angew. Chem. Int. Ed. (DOI: 10.1002/anie.201900711, 2019).
    Recent reports [Jara‐Toro et al., Angew. Chem. Int. Ed. 2017, 56, 2166 and PCCP 2018, 20, 27885] suggest that the rate coefficient of OH reactions with alcohols would increase by up to two times in going from dry to high humidity. This finding would have an impact on the budget of alcohols in the atmosphere and it may explain differences in measured and modeled methanol concentrations. The results were based on a relative technique carried out in a small Teflon bag, which might suffer from wall reactions. The effect was reinvestigated using a direct fluorescence probe of OH radicals, and no catalytic effect of H2O could be found. Experiments in a Teflon bag were also carried out, but the results of Jara‐Toro et al. were not reproducible. Further theoretical calculations show that the water‐mediated reactions have negligible rates compared to  ...
  • 曾文碧 博士
    Physical Chemistry Chemical Physics, 21, 9665-9671 (2019).
    The resonance-enhanced multiphoton ionization (REMPI) of a mixed sandwich complex has been achieved for the first time when exciting (η7-C7H7)(η5-C5H5)Cr via the Rydberg 4pz state. The REMPI spectrum is indicative of unexpectedly small changes of the sandwich geometry on excitation. Time- dependent DFT calculations reveal fine effects of the ligand nature on the molecular and electronic structure variations accompanying electronic excitation. Different trends are predicted for the sandwich geometry transformations in the mixed sandwich complex and its symmetric isomer, (η6-C6H6)2Cr, both on Rydberg excitation and ionization.
  • 余慈顏 博士
    Annals of Clinical and Translational Neurology, DOI:10.1002/acn3.50887
    Objective: Ala97Ser (A97S) is the major transthyretin (TTR) mutation in Taiwanese patients of familial amyloid polyneuropathy (FAP), characterized by a late-onset but rapidly deteriorated neuropathy. Tafamidis can restore the stability of some mutant TTR tetramers and slow down the progression of TTR-FAP. However, there is little understanding of the biophysical features of A97S-TTR mutant and the pharmacological modulation effect of tafamidis on it. This study aims to delineate the biophysical characteristics of A97S-TTR and the pharmacological modulation effect of tafamidis on this mutant.Method: The stability of TTR tetramers was assessed by urea denaturation and differential scanning calorimetry. Isothermal titration calorimetry (ITC) was used to measure the binding constant of tafamidis to TTR. Nuclear magnetic resonance spectroscopy (NMR) tit ...
  • 謝佳龍 博士
    ACS Nano, Just Accepted (2019).
    Single-molecule tracking is a powerful method to study molecular dynamics in living systems including biological membranes. High-resolution single-molecule tracking requires a bright and stable signal, which has typically been facilitated by nanoparticles due to their superb optical properties. However, there are concerns about using a nanoparticle to label a single molecule because of its relatively large size and the possibility of crosslinking multiple target molecules, both of which could affect the original molecular dynamics. In this work, using various labeling schemes, we investigate the effects of the use of nanoparticles to measure the diffusion of single membrane molecules. By conjugating a low density of streptavidin (sAv) to gold nanoparticles (AuNPs) of different sizes (10, 15, 20, 30, and 40 nm), we isolate and quantify the effect of ...
  • 陳應誠 博士
    Phys. Rev. Lett. 120, 183602 (2018).
    Quantum memory is a device that can store and then retrieve a quantum state on demand. It is an important building block in long-distance quantum communication. To outperform the direct transmission of photons with quantum repeaters, it is crucial to develop quantum memories with high fidelity, high efficiency and a long storage time. We achieved a storage efficiency of 92.0 % for a coherent optical memory based on the electromagnetically induced transparency scheme in optically dense cold atomic media. We also obtain a useful time-bandwidth product of 1200, considering only storage where the retrieval efficiency remains above 50 %. Both are the best record to date in all kinds of the schemes for the realization of optical memory. Our work significantly advances the pursuit of a high-performance optical memory and should have important applications ...
  • 高橋開人 博士
    Journal of Physical Chemistry A, 123, 5300-5308.
    Unsaturated carbon cluster chains often have chemical properties depending on the cluster size. While carbon cluster cation chains show odd−even variation in the reactivity with hydrogen, thechemistry of the carbon anion chain has been poorly understood even for the bimolecular reaction with hydrogen. We present a systematic theoretical study based on transition state calculations and molecular dynamics trajectory simulations for the reaction of Cn (n = 2−8) + H2. We show that carbon cluster chain anion also has an odd−even variation in reactivity where the even ones are more reactive. In addition, dynamics trajectory shows that while odd n only resulted in the CnH2 product with direct H insertion similar to the static reaction pathway, even  ...
  • 廖仲麒 博士
    Nature Communications, 9, 2023 (2018).
    Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather than pinwheels, intact DAPs exhibit a cone-shaped architecture with components filling the space between each pinwheel blade, a new structural element we term the distal appendage matrix (DAM). Specifically, CEP83, CEP89, SCLT1, and CEP164 form the backbone of pinwheel blades, with CEP83 confined at the root and CEP164 extending to the tip near the membrane-docking site. By contrast, FBF1 marks the distal end of the DAM near the ciliary membrane. Strikingly, unlike CEP164, which is essential for ciliogenesis, FBF1 is required for ciliary ...
  • 林育如 博士
    Physical Review Letters 121, 250401 (2018).
    We realize synthetic azimuthal gauge potentials for Bose-Einstein condensates along with spin-orbital-angular-momentum coupling. This is achieved by engineering atom-light interactions. We characterize the spin textures of the atoms and exploit the azimuthal gauge potential to demonstrate the Hess-Fairbank effect, the analogue of Meissner effect in superconductors. Our demonstration serves as a paradigm to create topological excitations by tailoring atom-light interactions where both types of SO(3) vortices in the     manifold, coreless vortices and polar-core vortices, are created in our experiment. The gauge field in the stationary Hamiltonian opens a path to investigating rotation properties of atomic superfluids under thermal equilibrium.
  • 陳貴賢 博士
    NATURE COMMUNICATIONS (DOI: 10.1038/s41467-017-02547-4, 2018)
    Carbon-doped SnS2 (SnS2-C) metal dichalcogenide nanostructure has been synthesized using a hydrothermal technique, which exhibits a highly active and selective photocatalytic conversion of CO2 to hydrocarbons under visible-light, attaining a photochemical quantum efficiency of above 0.7%. The SnS2 -C photocatalyst represents an important contribution towards high quantum efficiency artificial photosynthesis based on gas phase photocatalytic CO2 reduction under visible light.
  • 許良彥 博士
    Journal of Chemical Physics 151, 014105 (2019).
    We study a molecular emitter above a silver surface in the framework of macroscopic quantum electrodynamics and explore the population dynamics including non-Markovian effects. The theory we present is general for molecular fluorescence in the presence of dielectrics with any space-dependent, frequency-dependent, or complex dielectric functions. Furthermore, the proposed theory allows us to calculate the memory kernel of polaritons using computational electrodynamics packages. In the limit of a high vibration frequency, the different strengths of exciton-polariton couplings lead to distinct characteristics in the population dynamics, e.g., Franck-Condon-Rabi oscillation. (The frequency of Rabi oscillation is dependent on the Franck-Condon factor.) Additionally, in a specific condition, we derive a parameter-free formula that can be used to estimate ...
  • 謝佳龍 博士
    Nanoscale 11, 568-577 (2019).
    Nanoparticles have been used extensively in biology-related research and many applications require direct visualization of individual nanoparticles under optical microscopy. For long-term and high-speed measurements, scattering-based microscopy is a unique technique because of the stable and indefinite scattering signal. In scattering-based single-particle measurements, large nanoparticles are usually needed in order to generate sufficient signal for detection. However, larger nanoparticle introduces greater mass loading, experiences stronger steric hindrance, and is more prone to crosslinking. In this work, we demonstrate coherent brightfield (COBRI) microscopy with enhanced contrast and show its capability of direct visualization of very small nanoparticles in scattering at high speed. The COBRI microscopy allows us to visualize and track single  ...



Applications of Taiwan Biobank Resources to Metabolomics and Integrated Omics Research
張中科博士, 臺灣人體生物資料庫/ 中央研究院生物醫學科學研究所
2019-09-26 下午 03:30  浦大邦紀念講堂
A 30 Year Journey to the Synthesis of the First Enantiomerically-Enriched Molecular Sieve
Prof. Mark E. Davis, Warren and Katherine Schlinger Professor of Chemical Engineering at the California Institute of Technology, USA
2019-10-03 下午 03:30  浦大邦紀念講堂
Short-wave Infrared Photoluminescence: From Nanoparticles to Molecular Imaging
Dr. Ching-Wei Lin, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA
2019-10-15 上午 10:00  浦大邦紀念講堂
Robust Accurate Identification of Peptides and Proteins via Tandem Mass Spectrometry
于宜國教授, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, USA
2019-10-17 下午 03:30  浦大邦紀念講堂
Two-dimensional Electronic Transport Induced by Electron Surface Accumulation in MoS2
陳瑞山教授, 國立臺灣科技大學應用科技研究所
2019-10-24 下午 03:30  浦大邦紀念講堂


2019 MANA-i-MATE Joint Symposium
2019-11-04 上午 09:10 ~ 2019-11-05 下午 04:30
The International Center for Materials Nanoarchitectonics (MANA) was established at the National Institute for Materials Science (NIMS), Japan, in 2007. After a decade of successful development, MANA has grown into a representative international research center in the fields of nanotechnology and materials science, both in name and reality. The innovative Materials and Analytical Technology Exploration (i-MATE) Program was launched by Academia Sinica in 2018, aiming to provide a platform for encouraging researchers from different disciplines to find research partners to jointly conduct curiosity-driven exploratory researches in the areas of material or analytical technology. One of the important missions of the i-MATE Program is to help researchers in Academia Sinica to find domestic and international research-MATE. In the spirit of promoting international collaborations, the i-MATE Program is delighted to host this Symposium, hoping to bring together researchers from both institutions to share their academic experiences and research results in a relaxing atmosphere. We look forward to a successful gathering that helps pave the way to long-term collaborations among the researchers of NIMS and Academia Sinica.