Dr. Charles Pin-Kuang Lai (Biophysics and Bioanalytical Technology)
Tel of Office:
02-23668204
Selected Publications
- Magoling, B., Chen,Y., Wu, A.Y., Wong, W.W., Chou, S.T., Huang, H., Sung, Y., Hsieh, H., Huang, P., Lee, K., Huang, K., Chen,R., Chen,Y., Lai, C.P.* (2023). Membrane protein modification modulates big and small extracellular vesicle biodistribution and tumorigenic potential in breast cancers in vivo. Advanced Materials. 35(13): e2208966.
- Chien, J.C., Badr, C.E.*, Lai, C.P.* (2021). Multiplexed bioluminescence-mediated tracking of DNA double strand break repairs in vitro and in vivo. Nature Protocols. 16, 3933-3953. *Co-last authors.
- Wu, A.Y., Sung, Y., Chen, Y., Chou, S.T., Guo, V., Chien, J.C., Ko, J.J., Yang, A.L., Huang, H., Chuang, J., Wu, S., Ho, M., Ericsson, M., Lin, W., Cheung, C.H.Y., Juan, H., Ueda, K., Chen, Y., Lai, C.P. (2020). Multiresolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism. Advanced Science. 7 (19): 2001467-83.
- Chien J.C., Pinkham, K., da Hora, C.C., Tabet E., Badr C.E.*, Lai, C.P.* (2020). Multiplexed bioluminescent reporter enables real-time tracking of DNA double strand break repair dynamics in vitro and in vivo. Nucleic Acids Research. 48 (17): e100-117. *Co-last authors.
- Reátegui, E.,* van der Vos, K.E.,* Lai, C.P.,* Zeinali, M., Atai, N.A., Aldikacti, B., Floyd Jr., F.P., Khankhel, A.H., Thapar, V., Hochberg, F.H., Sequist, L.V., Nahed, B.V., Carter, B.S., Toner, M., Balaj, L., Ting, D.T., Breakefield, X.O., Stott, S.L. (2018). Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Nature Communications, 9 (1): 175-186.
- Pucci, F., Garris, C., Lai, C.P., Newton, A., Pfirschke, C., Engblom, C., Alvarez, D., Sprachman, M., Evavold, C., Magnuson, A., von Andrian, U.H., Glatz, K., Breakefield, X.O., Mempel, T.R., Weissleder, R., Pittet, M.J. (2016). SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science, 352 (6282): 242-6.
- Lai, C.P., Kim, K.Y., Badr, C.E., Mempel, T.R., Tannous, B.A., Breakefield, X.O. (2015). Visualization and tracking of tumor extracellular vesicles delivery and RNA translation using multiplexed reporters. Nature Communications, 6: 7029.1.
- Zaborowski, M., Breakefield, X.O., Lai, C.P. (2015). Extracellular vesicles: composition, biological relevance and methods of study. Bioscience, 65 (8): 783-797.
- Lai, C.P., Mardini, O., Ericsson, M., Prabhaker, S., Maguire A., Chen, J.W., Tannous, B.A., Breakefield, X.O. (2014). Dynamic biodistribution of extracellular vesicles in vivo using a multimodal reporter. ACS Nano, 8 (1): 483-94.
- Lai, C.P., Bechberger, J., Naus, C. (2009). Pannexin2 as a Novel Negative Growth Regulator in C6 Gliomas. Oncogene, 28 (49): 4402-8.
- Lai, C.P., Bechberger, J., Thompson, R.J., MacVicar, B., Bruzzone, R., Naus, C. (2007). Tumor-suppressive Effects of Pannexin1 in C6 Gliomas. Cancer Research, 67 (4): 1545-54.
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