中央研究院 原子與分子科學研究所
余慈顏 博士 (生物物理與分析技術組)
最新研究成果
Yi-Shan Wu, Li-Kang Chu,* Tsyr-Yan Yu*
J Phys Chem Lett .
Coccolithophores play critical roles in global carbon and sulfur cycles. They contribute to the carbon cycle through photosynthesis and calcification and the sulfur cycle by producing dimethylsulfoniopropionate (DMSP). Despite their ecological importance, the details and dynamics of methionine metabolism in coccolithophores are poorly understood. Here, we introduce an in situ light-coupled nuclear magnetic resonance (NMR) spectroscopy setup to monitor methionine metabolism directly in coccolithophore cultures under varying environmental conditions. Combining in situ light-coupled NMR spectroscopy and 13C magic angle spinning (MAS) spectroscopy, we observed that coccolithophores can take up methionine and convert it into 4-methylthio-2-oxobutyrate (MTOB), which is subsequently secreted into the culture medium, while DMSP was detected only intracellularly. Furthermore, environmental factors, such as elevated temperatures at 24.8 °C, which is 6.8 °C higher than the typical growth temperature for coccolithophores, and darkness, accelerated methionine consumption but reduced its incorporation into proteins and its conversion into MTOB, suggesting a shift toward alternative metabolic pathways under stress. In contrast, seawater acidification had minimal effects on the methionine metabolism. These findings provide new insights into how environmental conditions influence sulfur metabolism in coccolithophores, with potential consequences for their ecological functioning under future climate scenarios.
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最後更新於 2026-01-09 14:53:33
地址： 106319 台北市羅斯福路四段一號 或 106923 臺北臺大郵局 第23-166號信箱
電話：886-2-2362-0212 傳真：886-2-2362-0200 電子郵件：iamspublic@gate.sinica.edu.tw
最後更新於 2026-01-09 14:53:33
