中央研究院 原子與分子科學研究所

Recent advances in quantum technology have demonstrated the potential use of negatively charged nitrogen-vacancy (NV^–) centers in diamond for temperature and magnetic sensing at sub-cellular levels.  Fluorescent nanodiamonds (FNDs) containing high-density ensembles of NV^– centers are appealing for such applications because they are inherently biocompatible and non-toxic.  Here, we show that FNDs conjugated with gold nanorods (GNRs) are useful as a combined nanoheater and nanothermometer for highly localized hyperthermia treatment using near-infrared (NIR) lasers as the heating source.  A temperature rise of ~10 K can be readily achieved at a NIR laser power of 0.4 mW in cells.  The technique is compatible with the presence of static magnetic fields and allows for simultaneous temperature and magnetic sensing with nanometric spatial resolution.  To elucidate the nanoscale heating process, numerical simulations are conducted with finite element analysis, providing an important guideline for the use of this new tool for active and high-precision control of temperature under diverse environmental conditions.   

News/Highlights:
http://epjqt.epj.org/210-epj-qt/977-epjqt-highlight-gold-diamond-nanodevice-for-hyperlocalised-cancer-therapy

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