The Biophysics and Bioanalytical Technology Group consists of 5 Research Fellows and 1 Adjunct Research Fellow. The research aims of this group are: (1) understanding the physical principles governing biological processes with both theoretical and experimental approaches; (2) exploiting and developing new methods and tools based on optics, microscopy, and nanotechnology to interrogate complex biological systems at the molecular, cellular, and organismal levels. Owing to the strong interdisciplinary nature of these research projects, the group members have developed a rich network of collaborations with biologists, chemists, materials scientists, and physicists in Academia Sinica as well as in other major institutions in Taiwan.
Huan-Cheng Chang's research effort is focused on the development of diamond nanoparticles as protein extraction, isolation, purification, and crystallization devices, as well as the production of fluorescent nanodiamonds (FNDs) for superresolution imaging, long-term cell tracking, and nanoscale temperature sensing applications.
Chia-Lung Hsieh studies nanoscale biophysics by using advanced optical microscope techniques. His current research focuses on the development of high-speed scattering-based interference microscopy and its application in single-molecule membrane dynamics and chromatin remodeling in the cell nucleus.
Tsyr-Yan Yu is interested in three major research fields, including membrane protein research in a near-native environment, biophysics of transthyretin-related amyloid polyneuropathy and in-situ NMR development.
Charles P. Lai focuses on developing highly sensitive molecular bioimaging methods combined with molecular analysis functions to investigate intricate biological phenomena in vitro and in vivo, including extracellular vesicles (e.g., exosomes, microvesicles) and DNA repairs.
Ching-Wei Lin will be focusing on solving the challenges of translating short-wave infrared emissive nanoparticles into clinical applications, including chiral toxicity studies and biodegradable nanomedicine developments.
The adjunct member Yi-Chun Wu (NTU) is devoted to the studies of programmed cell death and cell migration in Caenorhabditis elegans using nanomaterials.