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張煥正 博士 研究成果

張煥正 博士
生物物理化學實驗室
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Research Articles (243)
  • N. Lu*, V. Elakkat, G. Gurumallappa, Z.-Y. Zheng, C.-F. Chiu, H.-C. Chang, P. B. So, and C.-H. Lin, “C(sp3)-F...F halogen bonds in fluorinated zinc metal complexes: fluorine as σ-hole donor and acceptor,” (submitted).
  • N. Lu*, V. Elakkat, G. Gurumallappa, Z.-Y. Zheng, C.-F. Chiu, H.-C. Chang, P. B. So, and C.-H. Lin, “sp3-based C-F…F halogen bonds with fluorine as both a σ-hole donor and an acceptor in fluorinated pyridinium salt,” (submitted).
  • N. Lu*, G. Gurumallappa, P.-Y. Liu, K.-L. Chan, Y.-C. Huang, Y.-C. Lin, E. Tessem, and H.-C. Chang, “Neutron diffraction studies of four examples of intramolecular tetrel bonds in fluorinated zinc complexes: The most red-shifted sp3 C-H stretch at 2688 cm-1,” (submitted).
  • W. W.-W. Hsiao*, S. Angela, T.-N. Le, G. Fadhilah, W.-H. Chiang, and H.-C. Chang, “Diagnostics of Alzheimer's disease using fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay,” (submitted).
  • S.-Y. Liang, M. I. C. Estayan, L.-W. Hsieh, M.-C. Pan, K. X. Li, H.-C. Chang, and W.-P. Peng*, “Real-time monitoring of the evaporation and fission of electrospray-ionized polystyrene beads and bacterial pellets at elevated temperatures,” Anal. Chem. 96, 7179–7186 (2024).
  • N. Varkentina, Y. Auad, S. Y. Woo, F. Castioni, J.-D. Blazit, M. Tencé, H.-C. Chang, J. Chen, K. Watanabe, T. Taniguchi, M. Kociak, and L. H. G. Tizei*, “Excitation lifetime extracted from electron–photon (EELS-CL) nanosecond-scale temporal coincidences,”Appl. Phys. Lett. 123, 223502 (2023) (6pp).
  • T.-I. Yang, Y.Y. Hui, J.-I. Lo, Y.-W. Huang, Y.-Y. Lee, B.-M. Cheng*, and H.-C. Chang*, “Imaging extreme ultraviolet radiation using nanodiamonds with nitrogen-vacancy centers,” Nano Lett. 23, 9811–9816 (2023).
  • H.-H. Lin, C.-Y. Wang, F.-J. Hsieh, F.-Z. Liao, Y.-K. Su, M. D. Pham, C.-Y. Lee, H.-C. Chang*, and H.-H. Hsu*, “Nanodiamonds in oil emulsions elicit potent immune responses for effective vaccination and therapeutics,” Nanomedicine 18, 1045–1059 (2023).
  • H. Wen, D. Kordahl, I. Kuschnerous, P. Reineck, A. Macmillan, H.-C. Chang, C. Dwyer, and S. L. Y. Chang*, “Correlative fluorescence and transmission electron microscopy assisted by 3D machine learning reveals thin nanodiamonds fluoresce brighter,” ACS Nano 17, 16491–16500 (2023).
  • T.-N. Le, H.-Y. Chen, X. M. Lam, C.-C. Wang, and H.-C. Chang*, “Antibody-conjugated nanodiamonds Imaging extreme ultraviolet radiation using fluorescent nanodiamonds with nitrogen-vacancy centersas dual-functional immunosensors for in vitro diagnostics,” Anal. Chem. 95, 12080–12088 (2023).
  • C.-S. Huang, C.-H. Hsiao, Y.-C. Chang, C.-H. Chang, J.-C. Yang, J. L. Gutmann, H.‐C. Chang, H.-M. Huang*, and S.-C. Hsieh*, “A novel endodontic approach in removing smear layer using nano and submicron diamonds with intracanal oscillation irrigation,” Nanomaterials 13, 1646 (2023) (16pp).
  • V. Elakkat, E. Tessema, C.-H. Lin, X. Wang*, H.-C. Chang, Y.-N. Zheng, Y.-C. Huang, G. Gurumallappa, Z.-Y. Zhang, K. L. Chan, H. A. Rahayu, J. S. Francisco, and N. Lu*, “Unusual changes of C–H bond lengths in chiral zinc complexes induced by noncovalent interactions,” Angew. Chem. Int. Ed. 62, e202215438 (2023) (8pp).
  • T.-I. Yang, T. Azuma, Y.-W. Huang, Y.-Y. Hui, C.-T. Chiang, and H.-C. Chang*, “Stimulated emission cross sections and temperature-dependent spectral shifts of neutral nitrogen-vacancy centers in diamonds,” J. Chin. Chem. Soc. 70, 451–459 (2023).
  • T.-N. Le, W. W.-W. Hsiao*, Y.-Y. Cheng, C.-C. Lee, T.-T. Huynh, M. D. Pham, M. Chen, M.-W. Jen, H.-C. Chang*, and W.-H. Chiang*, “Spin-enhanced lateral flow immunoassay for high-sensitivity detection of nonstructural protein NS1 serotypes of dengue virus,” Anal. Chem. 94, 17819–17826 (2022).
  • T.-I. Yang, Y.-W. Huang, P. Bista, C.-F. Ding, J. Chen, Y.-H. Chan, C.-T. Chiang*, and H.-C. Chang*, “Photoluminescence of nitrogen-vacancy centers by ultraviolet one- and two-photon excitation of fluorescent nanodiamonds,” J. Phys. Chem. Lett. 13, 11280–11287 (2022).
  • W. W.-W. Hsiao*, N. Sharma, T.-N. Le, Y.-Y. Cheng, C.-C. Lee, D.-T. Vo, Y.-Y. Hui, H.-C. Chang, and W.-H. Chiang*, “Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variants,” Anal. Chim. Acta 1230, 340389 (2022) (8pp).
  • Y. Y. Hui, Y.-X. Tang, T. Azuma, H.-H. Lin, F.-Z. Liao, Q.-Y. Chen, J.-H. Kuo, Y.-L. Wang, and H.-C. Chang*, “Design and implementation of a low-cost portable reader for thermometric lateral flow immunoassay,” J. Chin. Chem. Soc. 69, 1356–1365 (2022).
  • T. Azuma, Y. Y. Hui, O. Y. Chen, Y.-L. Wang, and H.-C. Chang*, “Thermometric lateral flow immunoassay with colored latex beads as reporters for COVID-19 testing,” Sci. Rep. 12, 3905 (2022) (12pp).
  • A. A. Patil, M. J. N. Descanzo, J. B. A. Agcaoili, C.-K. Chiang, C.-L. Cheng, H.-C. Chang, and W.-P. Peng*, “Carboxylated/oxidized diamond nanoparticles for quantifying immunoglobulin G antibodies using mass spectrometry,” ACS Appl. Nano Mater. 4, 8922–8936 (2021).
  • S. Meuret*, L. H.G. Tizei, F. Houdellier, Y. Auad, S. Weber, H.-C. Chang, M. Kociak and A. Arbouet*, “Time-resolved cathodoluminescence in an ultrafast transmission electron microscope,” Appl. Phys. Lett. 119, 062106 (2021) (6pp).
  • J. Chen*, O. Y. Chen*, and H.-C. Chang*, “Relaxation of a dense ensemble of spins in diamond under a continuous microwave driving field,” Sci. Rep. 11, 16278 (2021) (12pp).
  • T. T. Ho, V. T. Pham, T. T. Nguyen, T. V. Bao, V. T. Trinh, Q. M. Dang, H.-H. Lin, H. T. Bui, P. T. M. Nguyen, N. B. Pham, T. B. L. Thi, C. V. Phan, H.-C. Chang, W. W.-W. Hsiao, H. H. Chu*, and M. D. Pham*, “Effects of size and surface properties of nanodiamonds on the immunogenicity of recombinant H5 protein of A/H5N1 virus in mice,” Nanomaterials 11, 1597 (2021) (15pp).
  • Y. Y. Hui, O. Y. Chen, H.-H. Lin, Y.-K. Su, K. Chen, C.-Y. Wang, W. W.-W. Hsiao, and H.-C. Chang*, “Magnetically modulated fluorescence of nitrogen-vacancy centers in nanodiamonds for ultrasensitive biomedical analysis,” Anal. Chem. 93, 7140–7147 (2021).
  • N. Prabhakar*, I. Belevich, M. Peurla, X. Heiligenstein, H.-C. Chang, C. Sahlgren, E. Jokitalo, and J. M. Rosenholm, “Cell volume (3D) correlative microscopy facilitated by intracellular fluorescent nanodiamonds as multi-modal probes,” Nanomaterials 11, 14 (2021) (10pp).
  • S. Meuret, Y. Auad, L. Tizei, H.-C. Chang, F. Houdellier, M. Kociak, and A. Arbouet, “Time-resolved cathodoluminescence in a transmission electron microscope applied to NV centers in diamond,” Microsc. Microanal. 26 (S2), 2022-2023 (2020).
  • D. Duan, V. K. Kavatamane, S. R. Arumugam, Y.-K. Tzeng, H.-C. Chang, and G. Balasubramanian*, “Tapered ultra-high NA optical fiber tip for nitrogen-vacancy ensembles based endoscope in a fluidic environment,” Appl. Phys. Lett. 116, 113701 (2020) (6pp).
  • H.-C. Lu*, J.-I. Lo, Y.-C. Peng, S.-L. Chou, B.-M. Cheng*, and H.-C. Chang*, “Nitrogen-vacancy centers in diamond for high-performance detection of vacuum ultraviolet, extreme ultraviolet and X-rays,” ACS Appl. Mater. Interfaces 12, 3847−3853 (2020).
  • S.-J. Kuo, S.-W. Chang, Y. Y. Hui, O. Y. Chen, Y.-W. Chen, C.-C. Lin, D. Wan, H.-L. Chen*, and H.-C. Chang*, “Fluorescent microdiamonds conjugated with hollow gold nanoparticles as photothermal fiducial markers in tissue,” J. Mater. Chem. C 7, 15197−15207 (2019).
  • B.-M. Chang, L. Pan, H.-H. Lin, and H.-C. Chang*, “Nanodiamond-supported silver nanoparticles as potent and safe antibacterial agents,” Sci. Rep. 9, 13164 (2019) (11pp).
  • Y. Xu, Y. Su, Y. Yu, Y. Y. Hui, J. Cheng, H.-C. Chang, Y. Zhang, Y. R. Shen, and C. Tian*, “Mapping dynamical magnetic responses of ultra-thin superconducting films using nitrogen-vacancy centers in diamond,” Nano Lett. 19, 5697−5702 (2019).
  • L.-J. Su, H.-H. Lin, M.-H. Wu, L. Pan, K. Yadav, H.-H. Hsu, T.-Y. Ling, Y.-T. Chen, and H.-C. Chang*, “Intracellular delivery of luciferase with fluorescent nanodiamonds for dual-modality imaging of human stem cells,” Bioconjugate Chem. 30, 2228−2237 (2019).
  • Y. Y. Hui, O. Y. Chen, T. Azuma, B.-M. Chang, F.-J. Hsieh, and H.-C. Chang*, “All-optical thermometry with nitrogen-vacancy centers in nanodiamond-embedded polymer films,” J. Phys. Chem. C 123, 15366−15374 (2019).
  • F.-J. Hsieh, S. Sotoma, H.-H. Lin, C.-Y. Cheng, T.-Y. Yu, C.-L. Hsieh, C.-H. Lin*, and H.-C. Chang*, “Bioorthogonal fluorescent nanodiamonds for continuous long-term imaging and tracking of membrane proteins,” ACS Appl. Mater. Interfaces 11, 19774–19781 (2019).
  • D. Duan, V. K. Kavatamane, S. R. Arumugam, G. Rahane, G. Du, Y.-K. Tzeng, H.-C. Chang, and G. Balasubramanian*, “Laser induced heating in a high-density ensemble of nitrogen-vacancy centers in diamond and its effects on quantum sensing,” Opt. Lett. 44, 2851–2854 (2019).
  • F.-J. Hsieh, Y.-W. Chen, Y. Y. Hui, C.-H. Lin, and H.-C. Chang*, “Quantification and imaging of antigens on cell surface with lipid-encapsulated fluorescent nanodiamonds,” Micromachines 10, 304 (2019) (10pp).
  • D. Duan, G. Du, V. K. Kavatamane, G. Rahane, S. R. Arumugam, Y.-K. Tzeng, H.-C. Chang, and G. Balasubramanian*, “Efficient nitrogen-vacancy centers' fluorescence excitation and collection from micrometer-sized diamond by a tapered optical fiber in endoscope-type configuration,” Opt. Express 27, 6734–6745 (2019).
  • S.-Y. Liang, A. A. Patil, C.-H. Han, S.-W. Chou, W. Chang, P.-C. Soo, H.-C. Chang, and W.-P. Peng*, “Ionization of submicron-sized particles by laser-induced RF plasma for mass spectrometric analysis,” Anal. Chem. 90, 13236–13242 (2018).
  • S.-J. Kuo, P.-C. Tsai, Y.-C. Lee, S.-W. Chang, S. Sotoma, C.-Y. Fang, H.-C. Chang, and H.-L. Chen*, “Manipulating the distribution of electric field intensity to effectively enhance the spatial and spectral fluorescence intensity of fluorescent nanodiamonds,” Nanoscale 10, 17576–17584 (2018).
  • S. Sotoma*, F.-J. Hsieh, and H.-C. Chang*, “Single-step metal-free grafting of cationic polymer brushes on fluorescent nanodiamonds,” Materials 11, 1479 (2018) (9pp). 
  • Duan, V. K. Kavatamane, S. R. Arumugam, G. Rahane, Y.-K. Tzeng, H.-C. Chang, H. Sumiya, S. Onoda, J. Isoya, and G. Balasubramanian*, “Enhancing fluorescence excitation and collection from the nitrogen-vacancy center in diamond through a micro-concave mirror,” Appl. Phys. Lett. 113, 041107 (2018) (5pp). 
  • P. R. Dolan, S. Adekanye, A. A. P. Trichet, S. Johnson, L. Flatten, Y. C. Chen, L. Weng, D. Hunger, H.-C. Chang, S. Castelletto, and J. M. Smith*, “Robust, tunable, and high purity triggered single photon source at room temperature using a nitrogen-vacancy defect in diamond in an open microcavity,” Opt. Express 26, 7056–7065 (2018).
  • J. Zhao, Y. Cheng, H. Shen, Y. Y. Hui, T. Wen, H.-C. Chang, Q. Gong, and G. Lu*, “Light emission from plasmonic nanostructures enhanced with fluorescent nanodiamonds,” Sci. Rep. 8, 3605 (2018) (8pp). 
  • H. Lourenco-Martins, M. Kociak, S. Meuret, F. Treussart, Y. H. Lee, X. Y. Ling, H.-C. Chang, and L. H. G. Tizei*, “Probing plasmon-NV0 coupling at the nanometer scale with photons and fast electrons,” ACS Photonics 5, 324–328 (2018).
  • S. Sotoma*, F.-J. Hsieh, Y.-W. Chen, P.-C. Tsai, and H.-C. Chang*, “Highly stable lipid-encapsulation of fluorescent nanodiamonds for bioimaging applications,” Chem. Commun. 54, 1000–1003 (2018). 
  • F.-J. Hsieh, Y.-W. Chen, Y.-K. Huang, H.-M. Lee, C.-H. Lin, and H.-C. Chang*, “Correlative light-electron microscopy of lipid-encapsulated fluorescent nanodiamonds for nanometric localization of cell surface antigens,” Anal. Chem. 90, 1566–1571 (2018).
  • N. Prabhakar, M. Peurla, S. Koho, T. Deguchi, T. Näreoja, H.-C. Chang, J. M. Rosenholm*, and P. E. Hänninen, “STED-TEM correlative microscopy leveraging nanodiamonds as intracellular dual-contrast markers,” Small 14, 1701807 (2018) (7pp). 
  • H.-C. Lu*, Y.-C. Peng, S.-L. Chou, J.-I. Lo, B.-M. Cheng*, and H.-C. Chang*, “Far-UV excited luminescence of nitrogen-vacancy centers: Evidence for diamonds in space,” Angew. Chem. Int. Ed. 56, 14469–14473 (2017). 
  • N. B. Pham, T. T. Ho, G. T. Nguyen, T. T. Le, N. T. Le, H.-C. Chang, M. D. Pham, U. Conrad, and H. H. Chu*, “Nanodiamond enhances immune responses in mice against recombinant HA/H7N9 protein,” J. Nanobiotechnol. 15, 69 (2017) (12pp). 
  • V. I. Korepanov, H. Hamaguchi*, E. Osawa, V. Ermolenkov, I. Lednev, B. J. M. Etzold, O. Levinson, B. Zousman, C. P. Epperla, and H.-C. Chang, “Carbon structure in nanodiamonds elucidated from Raman spectroscopy,” Carbon 121, 322–329 (2017).
  • Y.-W. Chen, C.-H. Lee, Y.-L. Wang, T.-L. Li, and H.-C. Chang*, “Nanodiamonds as nucleating agents for protein crystallization,” Langmuir 33, 6521–6527 (2017). 
  • N. Prabhakar, M. H. Khan, M. Peurla, H.-C. Chang, P. E. Hänninen, and J. M. Rosenholm*, “Intracellular trafficking of fluorescent nanodiamonds and regulation of their cellular toxicity,” ACS Omega 2, 2689–2693 (2017).
  • M. D. Pham, C. P. Epperla, C.-L. Hsieh, W. Chang, and H.-C. Chang*, “Glycosaminoglycans-specific cell targeting and imaging using fluorescent nanodiamonds coated with viral envelope proteins,” Anal. Chem. 89, 6527–6534 (2017).  
  • S. Haziza*, N. Mohan, Y. Loe-Mie, A.-M. Lepagnol-Bestel, S. Massou, M.-P. Adam, X. L. Le, J. Viard, C. Plancon, R. Daudin, P. Koebel, E. Dorard, C. Rose, F.-J. Hsieh, C.-C. Wu, B. Potier, Y. Herault, C. Sala, A. Corvin, B. Allinquant, H.-C. Chang, F. Treussart*, and M. Simonneau*, "Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain disease-related genetic risk factors,” Nat. Nanotechnol. 12, 322–328 (2017).
  • L.-J. Su, M.-H. Wu, Y. Y. Hui, B.-M. Chang, L. Pan, P.-C. Hsu, Y.-T. Chen, H.-N. Ho, Y.-H. Huang, T.-Y. Ling*, H.-H. Hsu*, and H.-C. Chang*, “Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs,” Sci. Rep. 7, 45607 (2017) (11pp).  
  • P.-C. Tsai, C. P. Epperla, J.-S. Huang, O. Y. Chen, C.-C. Wu, and H.-C. Chang*, “Measuring nanoscale thermostability of cell membranes with single gold-diamond nanohybrids,” Angew. Chem. Int. Ed. 56, 3025–3030 (2017).
  • K.-K. Liu, W.-R. Qiu, E. N. Raj, H.-F. Liu, H.-S. Huang, Y.-W. Lin, C.-J. Chang, T.-H. Chen, C. Chen, H.-C. Chang, J.-K. Hwang, and J.-I. Chao*, “Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway,” Autophagy 13, 187–200 (2017). 
  • C. Xiong, X. Zhou, Q. He, X. Huang, J. Wang, W.-P. Peng, H.-C. Chang, and Z. Nie*, “The development of visible-wavelength MALDI cell mass spectrometry (CMS) for high-efficiency single-cell analysis,” Anal. Chem. 88, 11913–11918 (2016).
  • H. Kaupp, T. Hümmer, B. Schlederer, H.-C. Chang, H. Fedder, R. Reuter, T. W. Hänsch, and D. Hunger*, “Purcell-enhanced single-photon emission from nitrogen-vacancy centers coupled to a tunable microcavity,” Phys. Rev. Appl. 6, 054010 (2016).
  • C. H. Nee, S. L. Yap, T. Y. Tou, H.-C. Chang, and S. S. Yap*, “Direct synthesis of nanodiamonds by femtosecond laser irradiation of ethanol,” Sci. Rep. 6, 33966 (2016) (8pp).
  • H. Shen, R. Y. Chou, Y. Y. Hui, Y. He, Y. Cheng, H.-C. Chang, L. Tong, Q. Gong, and G. Lu*, “Directional fluorescence emission from a compact plasmonic-diamond hybrid nanostructure,” Laser Photon. Rev. 10, 647–655 (2016).
  • N. Zhang, K. Zhu, C. Xiong, Y. Jiang, H.-C. Chang, and Z. Nie*, “Mass measurement of single intact nanoparticles in a cylindrical ion trap,” Anal. Chem. 88, 5958–5962 (2016).
  • S. Nagarajan, C. Pioche-Durieu, L. H. G. Tizei, C.-Y. Fang, J.-R. Bertrand, E. Le Cam, H.-C. Chang, F. Treussart*, and M. Kociak*, “Simultaneous cathodoluminescence and electron microscopy cytometry of cellular vesicles labeled with fluorescent nanodiamonds,” Nanoscale 8, 11588–11594 (2016).
  • M. D. Pham, T.-C. Wen, H.-C. Li, P.-H. Hsieh, Y.-R. Chen, H.-C. Chang*, and C.-C. Han*, “Streamlined membrane proteome preparation for shotgun proteomics analysis with Triton X-100 cloud point extraction and nanodiamond solid phase extraction,” Materials 9, 385 (2016) (17pp).
  • M. K. Pola, M. V. R. Raju, C.-M. Lin, R. Putikam, M.-C. Lin, C. P. Epperla, H.-C. Chang, S.-Y. Chen, and H.-C. Lin*, “A fully-aqueous red-fluorescent probe for selective optical sensing of Hg2+ and its application in living cells,” Dyes Pigments 130, 256–265 (2016).
  • C. P. Epperla, O. Y. Chen, and H.-C. Chang*, “Gold/diamond nanohybrids may reveal how hyperlocalized hyperthermia kills cancer cells,” Nanomedicine 11, 443–445 (2016).
  • B. Yang, C.-Y. Fang, H.-C. Chang, F. Treussart, J.-B. Trebbia, and B. Lounis*, “Polarization effects in lattice-STED microscopy,” Faraday Discuss. 184, 37–49 (2015).
  • C. P. Epperla, N. Mohan, C.-W. Chang, C.-C. Chen, and H.-C. Chang*, “Nanodiamond-mediated intercellular transport of proteins through membrane tunneling nanotubes,” Small 11, 6097–6105 (2015).
  • K.-H. Chen, D. J. Lundy, E. K. W. Toh, C.-H. Chen, C. Shih, P. Chen, H.-C. Chang, J. J. Lai, P. S. Stayton, A. S. Hoffman, and P. C. H. Hsieh*, “Nanoparticle distribution during systemic inflammation is size-dependent and organ-specific,” Nanoscale 7, 15863–15872 (2015).
  • H.-H. Lin, H.-W. Lee, R.-J. Lin, C.-W. Huang, Y.-C. Liao, J.-M. Fang, Y.-T. Chen, T.-C. Lee, A. L. Yu*, and H.-C. Chang*, “Tracking and finding slow-proliferating/quiescent cancer stem cells with fluorescent nanodiamonds,” Small 11, 4394–4402 (2015).
  • P.-C. Tsai, O. Y. Chen, Y.-K. Tzeng, Y. Y. Hui, J. Y. Guo, C.-C. Wu, M.-S. Chang*, and H.-C. Chang*, “Gold/diamond nanohybrids for quantum sensing applications,” EPJ Quantum Technol. 2, 19 (2015) (12pp).
  • C.-L. Lin, C.-H. Lin, H.-C. Chang*, and M.-C. Su*, “Protein attachment on nanodiamonds,” J. Phys. Chem. A 119, 7704–7711 (2015).
  • Z. Chu, K. Miu, P. Lung, S. Zhang, S. Zhao, H.-C. Chang, G. Lin, and Q. Li*, “Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery,” Sci. Rep. 5, 11661 (2015) (8pp).
  • Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
  • T. Plakhotnik*, H. Aman, and H.-C. Chang, “All-optical single-nanoparticle ratiometric thermometry with a noise floor of 0.3 K•Hz–1/2,” Nanotechnology 26, 245501 (2015) (7pp).
  • R. Silbajoris, W. Linak, O. Shenderova, C. Winterrowd, H.-C. Chang, J. L. Zweier, A. Kota, L. A. Dailey, P. A. Bromberg, and J. M. Samet*, “Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation,” Diamond Relat. Mater. 58, 16–23 (2015).
  • S. Meuret, L. H. G. Tizei, T. Cazimajou, R. Bourrellier, H.-C. Chang, F. Treussart, and M. Kociak*, “Photon bunching in cathodoluminescence,” Phys. Rev. Lett. 114, 197401 (2015) (5pp).
  • T. Zhang, H. Cui, C.-Y. Fang, K. Cheng, X. Yang, H.-C. Chang, and M. L. Forrest*, “Targeted nanodiamonds as phenotype-specific photoacoustic contrast agents for breast cancer,” Nanomedicine 10, 573–587 (2015).
  • A. Singh, R. Singh, M. Shellaiah, E. C. Prakash, H.-C. Chang, P. Raghunath, M.-C. Lin, and H.-C. Lin*, “A new pyrene-based aggregation induced ratiometric emission probe for selective detections of trivalent metal ions and its living cell application,” Sensor. Actuat. B-Chem. 207, 338–345 (2015).
  • C.-Y. Fang, C.-C. Chang, C.-Y. Mou, and H.-C. Chang*, “Preparation and characterization of ion-irradiated nanodiamonds as photoacoustic contrast agents,” J. Nanosci. Nanotech. 15, 1037−1044 (2015).
  • Y.-A. Huang, C.-W. Kao, K.-K. Liu, H.-S. Huang, M.-H. Chiang, C.-R. Soo, H.-C. Chang, T.-W. Chiu*, J.-I. Chao*, and E. Hwang*, “The effect of fluorescent nanodiamonds on neuronal survival and morphogenesis,” Sci. Rep. 4, 6919 (2014) (10pp).
  • M. Kayci, H.-C. Chang, and A. Radenovic*, “Electron spin resonance of nitrogen-vacancy defects embedded in single nanodiamonds in an ABEL trap,” Nano Lett. 14, 5335–5341 (2014).
  • Y. Y. Hui, L.-J. Su, O. Y. Chen, Y.-T. Chen, T.-M. Liu, and H.-C. Chang*, “Wide-field imaging and flow cytometric analysis of cancer cells in blood by fluorescent nanodiamond labeling and time gating,” Sci. Rep. 4, 5574 (2014) (7pp).
  • T.-R. Kuo, W.-Y. Lai, C.-H. Li, Y.-Z. Wen, H.-C. Chang, J.-S. Chen, P.-C. Yang, and C.-C. Chen*, “AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging,” Nano Res. 7, 658–669 (2014).
  • T.-C. Hsu, K.-K. Liu, H.-C. Chang, E. Hwang, and J.-I. Chao*, “Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds,” Sci. Rep. 4, 5004 (2014) (11pp).
  • C. Xiong, X. Zhou, N. Zhang, L. Zhan, S. Chen, W.-P. Peng, H.-C. Chang, and Z. Nie*, “Quantitative assessment of protein adsorption on microparticles with particle mass spectrometry,” Anal. Chem. 86, 3876–3881 (2014).
  • Z. Chu, S. Zhang, B. Zhang, C. Zhang, C.-Y. Fang, I. Rehor, P. Cigler, H.-C. Chang, G. Lin, R. Liu, and Q. Li*, “Unambiguous observation of shape effects on cellular fate of nanoparticles,” Sci. Rep. 4, 4495 (2014) (9pp).
  • Y. Nawa, W. Inami, S. Lin, Y. Kawata*, S. Terakawa, C.-Y. Fang, and H.-C. Chang, “Multi-color imaging of fluorescent nanodiamonds in living HeLa cells using direct electron-beam excitation,” ChemPhysChem 15, 721–726 (2014).   
  • X. Yang, Y.-K. Tzeng, Z. Zhu, Z. Huang, X. Chen, Y. Liu, H.-C. Chang, L. Huang*, W.-D. Li*, and P. Xi*, “Sub-diffraction imaging of nitrogen-vacancy centers in diamond by stimulated emission depletion and structured illumination,” RSC Adv. 4, 11305–11310 (2014).
  • M. V. R. Raju, E. C. Prakash, H.-C. Chang, and H.-C. Lin*, “A facile ratiometric fluorescent chemodosimeter for hydrazine based on Ing-Manske hydrazinolysis and its applications in living cells,” Dyes Pigments 103, 9–20 (2014).
  • T.-R. Kuo, D.-Y. Wang, Y.-C. Chiu, Y.-C. Yeh, W.-T. Chen, C.-H. Chen, C.-W. Chen, H.-C. Chang, C.-C. Hu, and C.-C. Chen*, “Layer-by-layer thin film of reduced graphene oxide and gold nanoparticles as an effective sample plate in laser-induced desorption/ionization mass spectrometry,” Anal. Chim. Acta 809, 97–103 (2014).
  • L. H. G. Tizei, S. Meuret, S. Nagarajan, F. Treussart, C.-Y. Fang, H.-C. Chang, and M. Kociak*, “Spatially and spectrally resolved cathodoluminescence with fast electrons: A tool for background subtraction in luminescence intensity second-order correlation measurements applied to subwavelength inhomogeneous diamond nanocrystals,” Phys. Status Solidi A 210, 2060–2065 (2013).
  • H. Kaupp, C. Deutsch, H.-C. Chang, J. Reichel, T. W. Hänsch, and D. Hunger*, “Scaling laws of the cavity enhancement for nitrogen-vacancy centers in diamond,” Phys. Rev. A 88, 053812 (2013) (8pp).
  • B.-M. Chang, H.-H. Lin, L.-J. Su, W.-D. Lin, R.-J. Lin, Y.-K. Tzeng, R. T. Lee, Y. C. Lee, A. L. Yu*, and H.-C. Chang*, “Highly fluorescent nanodiamonds protein-functionalized for cell labeling and targeting,” Adv. Funct. Mater. 23, 5737–5745 (2013).
  • H.-C. Li, F.-J. Hsieh, C.-P. Chen, M.-Y. Chang, P. C. H. Hsieh, C.-C. Chen, S.-U. Hung, C.-C. Wu, and H.-C. Chang*, “The hemocompatibility of oxidized diamond nanocrystals for biomedical applications," Sci. Rep. 3, 3044 (2013) (8pp).
  • T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nat. Nanotechnol. 8, 682–689 (2013).
  • Y. Kuo, T.-Y. Hsu, Y.-C. Wu*, and H.-C. Chang*, “Fluorescent nanodiamond as a probe for the intercellular transport of proteins in vivo,” Biomaterials 34, 8352–8360 (2013).
  • L.-J. Su, C.-Y. Fang, Y.-T. Chang, K.-M. Chen, Y.-C. Yu, J.-H. Hsu*, and H.-C. Chang*, “Creation of high density ensembles of nitrogen-vacancy centers in nitrogen-rich type Ib nanodiamonds,” Nanotechnology 24, 315702 (2013) (9pp).
  • A. Ermakova, G. Pramanik, J.-M. Cai, G. Algara-Siller, U. Kaiser, T. Weil, Y.-K. Tzeng, H.-C. Chang, L. P. McGuinness, M. B. Plenio, B. Naydenov*, and F. Jelezko, “Detection of a few metallo-protein molecules using color centers in nanodiamonds,” Nano Lett. 13, 3305−3309 (2013).
  • C. Xiong, X. Zhou, J. Wang, N. Zhang, W.-P. Peng, H.-C. Chang, and, Z. Nie*, “Ambient aerodynamic desorption/ionization method for microparticle mass measurement,” Anal. Chem. 85, 4370−4375 (2013).
  • C.-C. Hsieh, J. Y. Guo, S.-U. Hung, R. Chen, Z. Nie, H.-C. Chang, and C.-C. Wu*, “Quantitative analysis of oligosaccharides derived from sulfated glycosaminoglycans by nanodiamond-based affinity purification and MALDI MS,” Anal. Chem. 85, 4342–4349 (2013).
  • N. D. Lai*, O. Faklaris, D. Zheng, V. Jacques, H.-C. Chang, J.-F. Roch, and F. Treussart*, “Quenching nitrogen-vacancy center photoluminescence with infrared pulsed laser,” New J. Phys. 15, 033030 (2013) (14pp).
  • T. Zhang, H. Cui, C.-Y. Fang, L.-J. Su, S. Ren, H.-C. Chang, X. Yang, and M. L. Forrest*, “Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance,” J. Biomed. Opt. 18, 026018 (2013) (6pp).
  • C. M. T. Campbell, M. T. Fontana, B. C. Taggart, M.-C. Su*, C.-L. Lin, H.-C. Chang, and H.-J. Chen, “Acid denaturation and refolding of cytochrome c on silica surface,” J. Chin. Chem. Soc. 60, 140–152 (2013).
  • Y. Y. Hui, Y.-C. Lu, L.-J. Su, C.-Y. Fang, J.-H. Hsu, and H.-C. Chang*, “Tip-enhanced sub-diffraction fluorescence imaging of nitrogen-vacancy centers in nanodiamonds,” Appl. Phys. Lett. 102, 013102 (2013) (4pp).
  • S.-W. Chou, G.-R. Shiu, H.-C. Chang, and W.-P. Peng*, “Wavelet-based method for time-domain noise analysis and reduction in a frequency-scan quadrupole ion trap mass spectrometer,” J. Am. Soc. Mass Spectrom. 23, 1855–1864 (2012).
  • V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012).
  • L.-H. Chen, T.-S. Lim*, and H.-C. Chang, “Measuring the number of (N-V)− centers in single fluorescent nanodiamonds in the presence of quenching effects,” J. Opt. Soc. Am. B 29, 2309–2313 (2012).
  • B. Zhang, C.-Y. Fang, C.-C. Chang, R. Peterson, S. Maswadi, R. D. Glickman, H.-C. Chang, and J. Y. Ye*, “Photoacoustic emission from fluorescent nanodiamonds enhanced with gold nanoparticles,” Biomed. Opt. Express 3, 1662–1669 (2012).
  • R. Chen, C. Xiong, X. Zhou, C.-C. Wu*, X. Ding, Z. Nie*, and H.-C. Chang, “N-(1-naphthyl) ethylenediamine dinitrate: A new matrix for negative ion MALDI-TOF MS analysis of small molecules,” J. Am. Soc. Mass Spectrom. 23, 1454–1460 (2012).
  • X. Y. Zhou, C. Q. Xiong, J. N. Wang, R. Chen, Y. Tang, H. X. Qiao, W.-P. Peng, H.-C. Chang, and Z. X. Nie*, “The development of charge detection quadrupole ion trap mass spectrometry (CD-ITMS) driven by rectangular and triangular waves,” Analyst 137, 1199–1204 (2012).
  • R. Chen, W. J. Xu, C. Q. Xiong, X. Y. Zhou, S. X. Xiong, Z. X. Nie*, L. Q. Mao, and H.-C. Chang*, “High-salt-tolerance matrix for facile detection of glucose in rat brain microdialysates by MALDI mass spectrometry,” Anal. Chem. 84, 465–469 (2012).
  • C.-Y. Fang, V. Vaijayanthimala, C.-A. Cheng, S.-H. Yeh, C.-F. Chang, C.-L. Li, and H.-C. Chang*, “The exocytosis of fluorescent nanodiamond and its use as a long-term cell tracker,” Small 7, 3363–3370 (2011).
  • C. Q. Xiong, X. Y. Zhou, R. Chen, Y. M. Zhang, W.-P. Peng, Z. X. Nie*, H.-C. Chang, H. W. Liu*, and Y. Chen, “Characterization of column packing materials in high-performance liquid chromatography by charge-detection quadrupole ion trap mass spectrometry,” Anal. Chem. 83, 5400–5406 (2011).
  • M. Yamanaka, Y.-K. Tzeng, S. Kawano, N. I. Smith, S. Kawata, H.-C. Chang, and K. Fujita*, “SAX microscopy with fluorescent nanodiamond probes for high-resolution fluorescence imaging,” Biomed. Opt. Express 2, 1946–1954 (2011).
  • J.-H. Hsu*, W.-D. Su, K.-L. Yang, Y.-K. Tzeng, and H.-C. Chang, “Non-blinking green emission from single H3 color centers in nanodiamonds,” Appl. Phys. Lett. 98, 193116 (2011) (3pp).
  • Y.-Y. Chen, H. Shu, Y. Kuo, Y.-K. Tzeng, and H.-C. Chang*, “Measuring Förster resonance energy transfer between fluorescent nanodiamonds and near-infrared dyes by acceptor photobleaching,” Diamond Relat. Mater. 20, 803–807 (2011).
  • Y. Y. Hui*, Y.-R. Chang, N. Mohan, T.-S. Lim, Y.-Y. Chen, and H.-C. Chang*, “Polarization modulation spectroscopy of single fluorescent nanodiamonds with multiple nitrogen-vacancy centers,” J. Phys. Chem. A 115, 1878–1884 (2011).
  • Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
  • L. Rondin, G. Dantelle*, A. Slablab, F. Treussart, P. Bergonzo, S. Perruchas, T. Gacoin, H.-C. Chang, V. Jacques*, and J.-F. Roch, “Surface-induced charge state conversion of nitrogen-vacancy defects in nanodiamonds,” Phys. Rev. B 82, 115449 (2010) (5pp).
  • N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
  • Y.-C. Chang, C.-N. Huang, C.-H. Lin, H.-C. Chang, and C.-C. Wu*, “Mapping protein cysteine sulfonic acid modifications with specific enrichment and mass spectrometry: An integrated approach to explore the cysteine oxidation,” Proteomics 10, 2961−2971 (2010).
  • Y. Y. Hui, B. Zhang, Y.-C. Chang, C.-C. Chang, H.-C. Chang*, J.-H. Hsu, K. Chang, and F.-H. Chang, “Two-photon fluorescence correlation spectroscopy of lipid-encapsulated fluorescent nanodiamonds in living cells,” Opt. Express 18, 5896–5905 (2010).
  • N. Mohan, Y.-K. Tzeng, L. Yang, Y.-Y. Chen, Y. Y. Hui, C.-Y. Fang, and H.-C. Chang*, “Sub-20-nm fluorescent nanodiamonds as photostable biolabels and fluorescence resonance energy transfer donors,” Adv. Mater. 22, 843–847 (2010).
  • B. Zhang, Y. Li, C.-Y. Fang, C.-C. Chang, C.-S. Chen, Y.-Y. Chen, and H.-C. Chang*, “Receptor-mediated cellular uptake of folate-conjugated fluorescent nanodiamonds: A combined ensemble and single-particle study,” Small 5, 2716–2721 (2009).
  • X. L. Kong, C. Lin, G. Infusini, H.-B. Oh, H. Jiang, K. Breuker, C.-C. Wu, O. P. Charkin, H.-C. Chang, and F. W. McLafferty*, “Numerous isomers of serine octamer ions characterized by infrared photodissociation spectroscopy,” ChemPhysChem 10, 2603–2606 (2009).
  • V. Vaijayanthimala, Y.-K. Tzeng, H.-C. Chang*, and C.-L. Li*, “The biocompatibility of fluorescent nanodiamonds and their mechanism of cellular uptake,” Nanotechnology 20, 425103 (2009) (9pp).
  • A. Zyubin, A. M. Mebel*, M. Hayashi, H.-C. Chang, and S.-H. Lin, “Quantum chemical modeling of photoabsorption properties of the two- and three-nitrogen-vacancy point defects in diamond,” J. Phys. Chem. C 113, 10432–10440 (2009).
  • C.-K. Lin*, H.-C. Chang, M. Hayashi, and S. H. Lin, “Excitation properties of the H3 defect center in diamond: A theoretical study,” Chem. Phys. Lett. 475, 68–72 (2009).
  • Y.-K. Tzeng, Z. Zhu, and H.-C. Chang*, “Alkali-hydroxide-doped matrices for structural characterization of neutral underivatized oligosaccharides by MALDI time-of-flight mass spectrometry,” J. Mass Spectrom. 44, 375–383 (2009).
  • T.-S. Lim, C.-C. Fu, K.-C. Lee, H.-Y. Lee, K. Chen, W.-F. Cheng, W. W. Pai, H.-C. Chang*, and W. Fann, “Fluorescence enhancement and lifetime modification of single nanodiamonds near a nanocrystalline silver surface,” Phys. Chem. Chem. Phys. 11, 1508–1514 (2009).
  • T.-L. Wee, Y.-W. Mau, C.-Y. Fang, H.-L. Hsu, C.-C. Han, and H.-C. Chang*, “Preparation and characterization of green fluorescent nanodiamonds for biological applications,” Diamond Relat. Mater. 18, 567–573 (2009).
  • A. S. Zyubin, A. M. Mebel*, M. Hayashi, H.-C. Chang, and S. H. Lin, “Quantum chemical modeling of photoabsorption properties of the nitrogen-vacancy point defect in diamond,” J. Comput. Chem. 30, 119–131 (2009).
  • Y. Y. Hui*, Y.-R. Chang*, T.-S. Lim, H.-Y. Lee, W. Fann, and H.-C. Chang*, “Quantifying the number of color centers in single fluorescent nanodiamonds by photon correlation spectroscopy and Monte Carlo simulation,” Appl. Phys. Lett. 94, 013104 (2009) (3pp).
  • A. S. Zyubin, A. M. Mebel*, H.-C. Chang, and S. H. Lin, “Potential energy surfaces for the lowest excited states of the nitrogen-vacancy point defects in diamonds: A quantum chemical study,” Chem. Phys. Lett. 462, 251–255 (2008).
  • C.-K. Lin*, Y.-H. Wang, H.-C. Chang, and S. H. Lin, “One- and two-photon absorption properties of diamond nitrogen-vacancy defect centers: A theoretical study,” J. Chem. Phys. 129, 124714 (2008).
  • Y.-K. Tzeng, C.-C. Chang, C.-N. Huang, C.-C. Wu, C.-C. Han, and H.-C. Chang*, “Facile MALDI-MS analysis of neutral glycans in NaOH-doped matrices: Microwave-assisted deglycosylation and one-step purification with diamond nanoparticles,” Anal. Chem. 80, 6809–6814 (2008).
  • C.-K. Chang, C.-C. Wu*, Y.-S. Wang, and H.-C. Chang, “Selective extraction and enrichment of multi-phosphorylated peptides using polyarginine-coated diamond nanoparticles,” Anal. Chem. 80, 3791–3797 (2008).
  • Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nat. Nanotechnol. 3, 284–288 (2008).
  • W.-P. Peng, H.-C. Lin, M. Chu, H.-C. Chang, H.-H. Lin, A. L Yu, and C.-H. Chen*, “Charge monitoring cell mass spectrometry,” Anal. Chem. 80, 2524–2530 (2008).
  • Z. X. Nie, F. P. Cui, M. Chu, C.-H. Chen, H.-C. Chang*, and Y. Cai*, “Calibration of a frequency-scan quadrupole ion trap mass spectrometer for microparticle mass analysis,” Int. J. Mass Spectrom. 270, 8–15 (2008).
  • Z. X. Nie, F. P. Cui, Y.-K. Tzeng, H.-C. Chang*, M. Chu, H.-C. Lin, C.-H. Chen, H.-H. Lin, and A. L. Yu, “High-speed mass analysis of whole erythrocytes by charge detection quadrupole ion trap mass spectrometry,” Anal. Chem. 79, 7401–7407 (2007).
  • C. M. Kraning, T. L. Benz, K. S. Bloome, G. C. Campanello, V. S. Fahrenbach, S. A. Mistry, C. A. Hedge, K. D. Clevenger, K. M. Gligorich, T. A. Hopkins*, G. C. Hoops*, S. B. Mendes, H.-C. Chang, and M.-C. Su*, “Determination of surface coverage and orientation of reduced cytochrome c on a silica surface with polarized ATR spectroscopy,” J. Phys. Chem. C 111, 13062–13067 (2007).
  • T.-L. Wee, Y.-K. Tzeng, C.-C. Han, H.-C. Chang*, W. Fann, J.-H. Hsu*, K.-M. Chen, and Y.-C. Yu, “Two-photon excited fluorescence of nitrogen-vacancy centers in proton-irradiated type Ib diamond,” J. Phys. Chem. A 111, 9379–9386 (2007).
  • C.-K. Lin*, H.-C. Chang, and S. H. Lin, “Symmetric double-well potential model and its application to vibronic spectra: Studies of inversion modes of ammonia and nitrogen-vacancy defect centers in diamond,” J. Phys. Chem. A 111, 9347–9354 (2007).
  • O. P. Charkin*, N. M. Klimenko, D. O. Charkin, H.-C. Chang, and S. H. Lin, “Theoretical DFT study of fragmentation and association of heme and hemin,” J. Phys. Chem. A 111, 9207–9217 (2007).
  • S. Sabu, F.-C. Yang, Y.-S. Wang, W.-H. Chen, H.-C. Chang, and C.-C. Han*, “Peptide analysis: Solid phase extraction-elution on diamond (SPEED) combined with atmospheric pressure MALDI-FTICR mass spectrometry,” Anal. Biochem. 367, 190–200 (2007).
  • W.-P. Peng, H.-C. Lin, H.-H. Lin, M.-L. Chu, A. L. Yu, H.-C. Chang, and C.-H. Chen*, “Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement,” Angew. Chem. Int. Ed. 46, 3865–3869 (2007).
  • T. T. B. Nguyen, H.-C. Chang*, and V. W.-K. Wu, “Adsorption and hydrolytic activity of lysozyme on diamond nanocrystallites,” Diamond Relat. Mater. 16, 872–876 (2007).
  • K. K. Liang*, C.-K. Lin, H.-C. Chang, A. A. Villaeys, M. Hayashi, and S. H. Lin, “Calculation of the vibrationally non-relaxed photo-induced electron transfer rate constant in dye-sensitized solar cells,” Phys. Chem. Chem. Phys. 9, 853–861 (2007).
  • C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA 104, 727–732 (2007).
  • W.-C. Chang, L.-C. L. Huang, Y.-S. Wang, W.-P. Peng, H.-C. Chang, N.-Y. Hsu, W.-B. Yang, and C.-H. Chen*, “Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited,” Anal. Chim. Acta 582, 1–9 (2007).
  • Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
  • K. K. Liang*, C.-K. Lin, H.-C. Chang, M. Hayashi, and S. H. Lin, “Theoretical treatments of ultrafast electron transfer from adsorbed dye molecule to semiconductor nanocrystalline surface,” J. Chem. Phys. 125, 154706 (2006) (16pp).
  • Y.-S. Wang, S. Sabu, S.-C. Wei, C.-M. J. Kao, X. L. Kong, S.-C. Liau, C.-C. Han, H.-C. Chang*, S.-Y. Tu, A. H. Kung, and J. Z. H. Zhang, “Dissociation of heme from gaseous myoglobin ions studied by infrared multiphoton dissociation spectroscopy and Fourier-transform ion cyclotron resonance mass spectrometry,” J. Chem. Phys. 125, 133310 (2006) (7pp).
  • W.-H. Chen, S.-C. Lee, S. Sabu, H.-C. Fang, S.-C. Chung, C.-C. Han*, and H.-C. Chang*, “Solid phase extraction and elution on diamond (SPEED): A fast and general platform for proteome analysis with mass spectrometry,” Anal. Chem. 78, 4228–4234 (2006).
  • X. L. Kong, I.-A. Tsai, S. Sabu, C.-C. Han, Y. T. Lee, H.-C. Chang*, S.-Y. Tu, A. H. Kung, and C.-C. Wu, “Progressive stabilization of zwitterionic structures in H+(Ser)2-8 studied by infrared photodissociation spectroscopy,” Angew. Chem. Int. Ed. 45, 4130–4135 (2006).
  • H.-C. Chang*, K. Chen, and S. Kwok*, “Nanodiamond as a possible carrier of extended red emission,” Astrophys. J. 639, L63–L66 (2006).
  • Z. X. Nie, C.-W. Lin, W.-P. Peng, Y. T. Lee, and H.-C. Chang*, “Frequency scan of a quadrupole mass analyzer in the third stability region for protein analysis,” J. Chin. Chem. Soc. 53, 47–52 (2006).
  • W.-P. Peng, Y.-C. Yang, M.-W. Kang, Y.-K. Tzeng, Z. X. Nie, H.-C. Chang*, W. Chang, and C.-H. Chen, “Laser-induced acoustic desorption mass spectrometry of single bioparticles,” Angew. Chem. Int. Ed. 45, 1423–1426 (2006).
  • S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
  • O. P. Charkin*, N. M. Klimenko, P. T. Nguyen, D. O. Charkin, A. M. Mebel, S. H. Lin, Y.-S. Wang, S.-C. Wei, and H.-C. Chang, “Fragmentation of heme and hemin+ with sequential loss of carboxymethyl groups: A DFT and mass-spectrometry study,” Chem. Phys. Lett. 415, 362–369 (2005).
  • W.-P. Peng, Y.-C. Yang, C.-W. Lin, and H.-C. Chang*, “Molar mass and molar mass distribution of polystyrene particle size standards,” Anal. Chem. 77, 7084–7089 (2005).
  • O. P. Charkin*, N. M. Klimenko, P. T. Nguyen, D. O. Charkin, Y.-S. Wang, S.-C. Wei, H.-C. Chang, and S. H. Lin, “Theoretical study of fragmentation of heme and its ion with successive removal of carboxymethyl groups,” Russ. J. Inorg. Chem. 50, 1398–1407 (2005).
  • X. L. Kong, L. C. L. Huang, S.-C. V. Liau, C.-C. Han, and H.-C. Chang*, “Polylysine-coated diamond nanocrystals for MALDI-TOF mass analysis of DNA oligonucleotides,” Anal. Chem. 77, 4273–4277 (2005).
  • C.-K. Lin, C.-C. Wu, Y.-S. Wang, Y. T. Lee, H.-C. Chang*, J.-L. Kuo*, and M. L. Klein, “Vibrational predissociation spectra and hydrogen-bond topologies of H+(H2O)9-11,” Phys. Chem. Chem. Phys. 7, 938–944 (2005).
  • C.-C. Wu, C.-K. Lin, H.-C. Chang*, J. C. Jiang, J.-L. Kuo*, and M. L. Klein, “Protonated clathrate cages enclosing neutral water molecules: H+(H2O)21 and H+(H2O)28,” J. Chem. Phys. 122, 074315 (2005) (9pp).
  • W.-P. Peng, Y. T. Lee, J. W. Ting*, and H.-C. Chang*, “Averaging peak-to-peak voltage detector for absolute mass determination of single particles with quadrupole ion traps,” Rev. Sci. Instrum. 76, 023108 (2005) (5pp).
  • X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259–265 (2005).
  • J.-W. Wang*, Y.-M. Chang, H.-C. Chang, S.-H. Lin, L.-C. L. Huang, X.-L. Kong, and M.-W. Kang, “Local structure dependence of the charge transfer band in nanocrystalline Y2O3: Eu3+,” Chem. Phys. Lett. 405, 314–317 (2005).
  • C. Chaudhuri, C.-C. Wu, J. C. Jiang, and H.-C. Chang*, “Comparative studies of H+(C6H6)(H2O)1,2 and H+(C5H5N)(H2O)1,2 by DFT calculations and IR spectroscopy,” Aust. J. Chem. 57, 1153–1156 (2004).
  • W.-P. Peng, Y.-C. Yang, M.-W. Kang, Y. T. Lee, and H.-C. Chang*, “Measuring masses of single bacterial whole cells with a quadrupole ion trap,” J. Am. Chem. Soc. 126, 11766–11767 (2004).
  • Y.-Y. Cheng, H.-C. Chang*, G. C. Hoops, and M.-C. Su, “Stabilization of yeast cytochrome c covalently immobilized on fused silica surfaces,” J. Am. Chem. Soc. 126, 10828–10829 (2004).
  • L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir 20, 5879–5884 (2004).
  • C.-C. Wu, Y.-S. Wang, C. Chaudhuri, J. C. Jiang, and H.-C. Chang*, “Microsolvation of the lithium ion by methanol in the gas phase,” Chem. Phys. Lett. 388, 457–462 (2004).
  • C.-C. Wu, C. Chaudhuri, J. C. Jiang, Y. T. Lee, and H.-C. Chang*, “Structural isomerism and competitive proton solvation between methanol and water in H+(CH3OH)m(H2O)n, m + n = 4,” J. Phys. Chem. A 108, 2859–2866 (2004).
  • A. P. Jones*, L. B. d’Hendecourt, S.-Y. Sheu, H.-C. Chang, C.-L. Cheng, and H. G. M. Hill, “Surface C-H stretching features on meteoritic nanodiamonds,” Astron. Astrophys. 416, 235–241 (2004).
  • Y.-Y. Cheng, S. H. Lin, H.-C. Chang*, and M.-C. Su, “Probing adsorption, orientation and conformational changes of cytochrome c on fused silica surfaces with the Soret band,” J. Phys. Chem. A 107, 10687–10694 (2003).
  • Y.-R. Chen, H.-C. Chang*, C.-L. Cheng, C.-C. Wang, and J. C. Jiang, “Size dependence of CH stretching features on diamond nanocrystal surfaces: Infrared spectroscopy and density functional theory calculations,” J. Chem. Phys. 119, 10626–10632 (2003).
  • W.-P. Peng, Y. Cai, Y. T. Lee, and H.-C. Chang*, “Laser-induced fluorescence/ion trap as a detector for mass spectrometric analysis of nanoparticles,” Int. J. Mass Spectrom. 229, 67–76 (2003).
  • C.-C. Wu, C. Chaudhuri, J. C. Jiang, Y. T. Lee, and H.-C. Chang*, “Hydration-induced conformational changes in protonated 2,4-pentanedione in the gas phase,” Mol. Phys. 101, 1285–1298 (2003).
  • K.-Y. Kim, H.-C. Chang*, Y. T. Lee, U.-I. Cho, and D. W. Boo, “Vibrational predissociation spectroscopic and ab initio theoretical studies on protonated ethylenediamine-(water)3 complex,” J. Phys. Chem. A 107, 5007–5013 (2003).
  • Y.-S. Wang, C.-H. Tsai, Y. T. Lee, H.-C. Chang*, J. C. Jiang, O. Asvany, S. Schlemmer, and D. Gerlich, “Investigations of protonated and deprotonated water clusters using a low-temperature 22-pole ion trap,” J. Phys. Chem. A 107, 4217–4225 (2003).
  • Y. Cai, W.-P. Peng, and H.-C. Chang*, “Ion trap mass spectrometry of fluorescently labeled nanoparticles,” Anal. Chem. 75, 1805–1811 (2003).
  • S.-Y. Sheu, I.-P. Lee, Y. T. Lee, and H.-C. Chang*, “Laboratory investigations of hydrogenated diamond surfaces by infrared spectroscopy: Implications for the formation and size of interstellar nanodiamonds,” Astrophys. J. 581, L55–L58 (2002).
  • J. C. Jiang, C. Chaudhuri, Y. T. Lee, and H.-C. Chang*, “Hydrogen bond rearrangements and interconversions of H+(CH3OH)4H2O cluster isomers,” J. Phys. Chem. A 106, 10937–10944 (2002).
  • C.-C. Wu, C. Chaudhuri, J. C. Jiang, Y. T. Lee, and H.-C. Chang*, “On the first overtone spectra of protonated water clusters [H+(H2O)3-5] in the free-OH stretch region,” J. Chin. Chem. Soc. 49, 769–775 (2002).
  • Y. Cai, W.-P. Peng, S.-J. Kuo, S. Sabu, C.-C. Han, and H.-C. Chang*, “Optical detection and charge-state analysis of MALDI-generated particles with molecular masses larger than 5 MDa,” Anal. Chem. 74, 4434–4440 (2002).
  • Y. Cai, W.-P. Peng, S.-J. Kuo, and H.-C. Chang*, “Calibration of an audio-frequency ion trap mass spectrometer,” Int. J. Mass Spectrom. 214, 63–73 (2002).
  • C.-F. Chen, C.-C. Wu, C.-L. Cheng, S.-Y. Sheu, and H.-C. Chang*, “The size of interstellar nanodiamonds revealed by infrared spectra of CH on synthetic diamond nanocrystal surfaces,” J. Chem. Phys. 116, 1211–1214 (2002).
  • Y. Cai, W.-P. Peng, S.-J. Kuo, Y. T. Lee, and H.-C. Chang*, “Single-particle mass spectrometry of polystyrene microspheres and diamond nanocrystals,” Anal. Chem. 74, 232–238 (2002).
  • C. Chaudhuri, J. C. Jiang, C.-C. Wu, X. Wang, and H.-C. Chang*, “Characterization of protonated formamide-containing clusters by infrared spectroscopy and ab initio calculations: II. Hydration of formamide in the gas phase,” J. Phys. Chem. A 105, 8906–8915 (2001).
  • C. Chaudhuri, Y.-S. Wang, J. C. Jiang, Y. T. Lee, H.-C. Chang*, and G. Niedner-Schatteburg, “Infrared spectra and isomeric structures of hydroxide-water cluster ions OH–(H2O)1-5: A comparison with H3O+(H2O)1-5,” Mol. Phys. 99, 1161–1173 (2001).
  • Y. D. Glinka*, K.-W. Lin, H.-C. Chang, S. H. Lin, and Y. T. Chen, “Power laser light-induced photoluminescence from detonation-synthesized 5nm-sized diamonds,” Defect Diffusion Forum 186-187, 37–44 (2000).
  • C.-C. Wu, J. C. Jiang, I. Hahndorf, C. Chaudhuri, Y. T. Lee, and H.-C. Chang*, “Characterization of protonated formamide-containing clusters by infrared spectroscopy and ab initio calculations: I. O-protonation,” J. Phys. Chem. A 104, 9556–9565 (2000).
  • C. Chaudhuri, J. C. Jiang, X. Wang, Y. T. Lee, and H.-C. Chang*, “Identification of CH3OH2+- and H3O+-centered isomers from fragment-dependent vibrational predissociation spectra of H+(CH3OH)4H2O,” J. Chem. Phys. 112, 7279–7282 (2000).
  • J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc. 122, 1398–1410 (2000).
  • H.-C. Chang*, J. C. Jiang, H.-C. Chang, L. R. Wang, and Y. T. Lee, “Hydrogen bond rearrangement and intermolecular proton transfer in protonated methanol clusters,” Israel J. Chem. 39, 231–243 (2000).
  • C.-C. Wu, J. C. Jiang, D. W. Boo, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Behaviors of an excess proton in solute-containing water clusters: A case study of H+(CH3OH)(H2O)1-6,” J. Chem. Phys. 112, 176–188 (2000).
  • I. Hahndorf, J. C. Jiang, H.-C. Chang, C.-C. Wu, and H.-C. Chang*, “Proton-assisted hydration at hydrophobic sites in protonated ether and keto dimers,” J. Phys. Chem. A 103, 8753–8761 (1999).
  • H.-C. Chang*, J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, and Y. T. Lee, “On the search for H5O2+-centered water clusters in the gas phase,” J. Chin. Chem. Soc. 46, 427–434 (1999).
  • R. Chang, J. C. Jiang, P.-J. Hsieh, H.-C. Chang, and S. H. Lin*, “Theory of vibrational predissociation spectroscopy,” J. Chin. Chem. Soc. 46, 417–426 (1999).
  • Y. D. Glinka, K.-W. Lin, H.-C. Chang, and S. H. Lin*, “Multiphoton-excited luminescence from diamond nanoparticles,” J. Phys. Chem. B 103, 4251–4263 (1999).
  • H.-C. Chang, J. C. Jiang, I. Hahndorf, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Migration of an excess proton upon asymmetric hydration: H+[(CH3)2O](H2O)n as a model system,” J. Am. Chem. Soc. 121, 4443–4450 (1999).
  • J. C. Jiang, H.-C. Chang, Y. T. Lee, and S. H. Lin*, “Ab initio studies of NH4+(H2O)1-5 and the influence of hydrogen-bonding nonadditivity on geometries and vibrations,” J. Phys. Chem. A 103, 3123–3135 (1999).
  • H.-C. Chang, J. C. Jiang, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Isomeric transitions between linear and cyclic H+(CH3OH)4,5: Implications for proton migration in liquid methanol,” J. Phys. Chem. A 103, 2941–2944 (1999).
  • H.-C. Chang, Y.-S. Wang, Y. T. Lee, and H.-C. Chang*, “Studying protonated ion hydration by infrared spectroscopy of size-selected NH4+(H2O)n clusters in a free jet expansion,” Int. J. Mass Spectrom. 179/180, 91–102 (1998).
  • C.-C. Chuang, S. N. Tsang, W. Klemperer*, and H.-C. Chang, “Vibrational predissociation dynamics of ArHF (3000) and (3110): Lifetimes and HF product state distributions,” J. Chem. Phys. 109, 8836–8841 (1998).
  • Y.-S. Wang, H.-C. Chang, J. C. Jiang, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Structures and isomeric transitions of NH4+(H2O)3-6: From single to double rings,” J. Am. Chem. Soc. 120, 8777–8788 (1998).
  • K.-W. Lin, C.-L. Cheng, and H.-C. Chang*, “Laser-induced intracluster reactions of oxygen-containing nanodiamonds,” Chem. Mater. 10, 1735–1737 (1998).
  • C.-C. Chuang, S. N. Tsang, W. Klemperer*, and H.-C. Chang, “Vibrational predissociation of an inert gas cluster containing an active molecule: The vHF = 3 spectrum of Ar3HF,” J. Chem. Phys. 109, 484–491 (1998).
  • J. C. Jiang, J.-C. Chang, B.-C. Wang, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “The free-OH stretching frequencies of 3-coordinated H2O in water clusters and on ice surfaces,” Chem. Phys. Lett. 289, 373–382 (1998).
  • Y.-S. Wang, J. C. Jiang, C.-L. Cheng, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Identifying 2- and 3-coordinated H2O in protonated ion-water clusters by vibrational predissociation spectroscopy and ab initio calculations,” J. Chem. Phys. 107, 9695–9698 (1997).
  • C.-C. Chuang, S. N. Tsang, J. G. Hanson, W. Klemperer*, and H.-C. Chang, “Laser-induced fluorescence spectroscopy of Ar2HF at vHF = 3: An examination of three-body forces,” J. Chem. Phys. 107, 7041–7056 (1997).
  • C.-C. Chuang, S. N. Tsang, W. Klemperer*, and H.-C. Chang, “Reassignment of the 11537 cm-1 band of hydrogen fluoride dimer and observation of the intermolecular combination mode 3ν1+ν4,” J. Phys. Chem. 101, 6702–6708 (1997).
  • C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3713–3716 (1997).
  • C.-L. Cheng, J.-C. Lin*, and H.-C. Chang*, “The absolute absorption strength and vibrational coupling of CH stretching on diamond C(111),” J. Chem. Phys. 106, 7411–7421 (1997).
  • W.-K. Liu, M. Hayashi, J.-C. Lin, H.-C. Chang, S. H. Lin*, and J.-K. Wang, “Effect of temperature on the infrared and sum-frequency generation spectra of adsorbates,” J. Chem. Phys. 106, 5920–5927 (1997).
  • C.-L. Cheng, J.-C. Lin*, H.-C. Chang*, and J.-K Wang, “Characterization of CH stretches on diamond C(111) single- and nanocrystals by infrared absorption spectroscopy,” J. Chem. Phys. 105, 8977–8978 (1996).
  • S. N. Tsang, C.-C. Chuang, R. Mollaaghababa, W. Klemperer*, and H.-C. Chang, “Intermolecular state dependence of the vibrational predissociation of N2-HF,” J. Chem. Phys. 105, 4385–4387 (1996).
  • J.-C. Lin*, K.-H. Chen, H.-C. Chang*, C.-S. Tsai, C.-E. Lin, and J.-K. Wang*, “The vibrational dephasing and relaxation of CH and CD stretches on diamond surfaces: An anomaly,” J. Chem. Phys. 105, 3975–3983 (1996).
  • H.-C. Chang* and W. Klemperer*, “A phenomenological model for the vibrational dependence of hydrogen interchange tunneling in HF dimer,” J. Chem. Phys. 104, 7830–7835 (1996).
  • H.-C. Chang* and J.-C. Lin*, “Structure and bonding of C2H2 on diamond C(111)-1x1:H: Infrared spectroscopy and exciton calculations,” J. Phys. Chem. 100, 7018–7025 (1996).
  • H.-C. Chang* and J.-C. Lin, “Infrared spectroscopy of adsorbed CO2 as a probe for the surface heterogeneity of diamond C(111)-1x1:H,” Appl. Phys. Lett. 67, 2474–2476 (1995).
  • H.-C. Chang*, J.-C. Lin, J.-Y. Wu, and K.-H. Chen, “Infrared spectroscopy and vibrational relaxation of CHx and CDx stretches on synthetic diamond nanocrystal surfaces,” J. Phys. Chem. 99, 11081–11088 (1995).
  • H.-C. Chang*, D. J. Dai, and G. E. Ewing, “Vibrational spectroscopy as a probe of surface heterogeneity: CO on NaCl(100),” J. Chin. Chem. Soc. 42, 317–324 (1995).
  • H.-C. Chang, F.-M. Tao, S. N. Tsang, and W. Klemperer*, “Dependence of the intermolecular potentials of ArHF and N2HF on HF bond length,” J. Chin. Chem. Soc. 42, 141–148 (1995).
  • R. Mollaaghababa, H.-C. Chang, and W. Klemperer*, “Vibrational predissociation of HFHCl by overtone excitation of HF,” Can. J. Phys. 72, 693–696 (1994).
  • S. N. Tsang, H.-C. Chang, and W. Klemperer*, “Characterization of N2HF at 3ν1 HF stretch,” J. Phys. Chem. 98, 7313–7318 (1994).
  • H.-C. Chang and W. Klemperer*, “High overtone spectroscopy and photodissociation of hydrogen fluoride complexes,” Faraday Discuss. 97, 95–103 (1994).
  • H.-C. Chang and W. Klemperer*, “The vibrational second overtones of HF dimer: A quartet,” J. Chem. Phys. 100, 1–14 (1994).
  • H.-C. Chang, F.-M. Tao, W. Klemperer*, C. Healey, and J. M. Hutson, “The Ar-HF intermolecular potential: Overtone spectroscopy and ab initio calculations,” J. Chem. Phys. 99, 9337–9349 (1993).
  • H.-C. Chang and W. Klemperer*, “State-specific vibrational predissociation and interconversion tunneling quenching at 3ν1 and 3ν2 of (HF)2,” J. Chem. Phys. 98, 9266–9278 (1993).
  • H.-C. Chang and W. Klemperer*, “Observation of ArHF(3000) and its combination modes by laser-induced fluorescence,” J. Chem. Phys. 98, 2497–2506 (1993).
  • H.-C. Chang and G. E. Ewing*, “Vibrational relaxation of molecules on alkali halide surfaces,” Proceedings Vibrations at Surfaces, New York, 1990; also in J. Electron Spectrosc. Relat. Phenom. 54, 39–63 (1990).
  • R. S. Disselkamp, H.-C. Chang, and G. E. Ewing*, “Infrared spectroscopy of CO on NaCl(100): IV. Bandshape analysis,” Surf. Sci. 240, 193–210 (1990).
  • H.-C. Chang and G. E. Ewing*, “Infrared fluorescence from a monolayer of CO on NaCl(100),” Phys. Rev. Lett. 65, 2125–2128 (1990).
  • H.-C. Chang and G. E. Ewing*, “Vibrational energy transfer and population inversion in CO overlayers on NaCl(100),” J. Phys. Chem. 94, 7635–7641 (1990).
  • H.-C. Chang, C. Noda, and G. E. Ewing*, “CO on NaCl(100): Model system for investigating vibrational energy flow,” J. Vac. Sci. Technol. A8, 2644–2648 (1990).
  • H.-C. Chang and G. E. Ewing*, “The quantum efficiency of vibrationally induced desorption for a monolayer of CO on NaCl(100),” Chem. Phys. 139, 55–65 (1989).
  • H. H. Richardson, H.-C. Chang, C. Noda, and G. E. Ewing*, “Infrared spectroscopy of CO on NaCl(100): I. Photometry,” Surf. Sci. 216, 93–104 (1989).
  • H.-C. Chang, H. H. Richardson, and G. E. Ewing*, “Epitaxial growth of CO on NaCl(100) studied by infrared spectroscopy,” J. Chem. Phys. 89, 7561–7568 (1988).
  • H.-C. Chang and K.-H. Houng*, “DMSO intercalation as a method in the identification of kaolinite from chlorite in soil clay samples,” Bull. Inst. Chem. Acad. Sinica 31, 31–39 (1984).
Review Articles (19)
  • S. Angela, G, Fadhilah, H.-Y. Lin, J. Ko, S. C.-W. Lu, C.-C. Lee, Y.-S. Chang, C.-Y. Lin, H.-C. Chang, W. W.-W. Hsiao*, and W.-H. Chiang, “Nanomaterials in the treatment and diagnosis of rheumatoid arthritis: Advanced approaches,” (submitted).
  • W. W.-W. Hsiao*, X. M. Lam, T.-N. Le, C.-A. Cheng*, and H.-C. Chang, “Exploring nanodiamonds: Leveraging their dual capacities for anticancer photothermal therapy and temperature sensing,” (submitted).  
  • W. W.-W. Hsiao*, G. Fadhilah, C.-C. Lee, R. Endo, Y.-J. Lin, S. Angela, C.-C. Ku, H.-C. Chang, and W.-H. Chiang*, “Nanomaterial-based biosensors for avian influenza virus: A new way forward,” Talanta 265, 124892 (2023) (14pp).
  • W. W.-W. Hsiao*, T.-N. Le, D. M. Pham, H.-H. Ko, H.-C. Chang, C.-K. Lee*, and W.-H. Chiang*, “Recent advances in novel lateral flow technologies for detection of COVID-19,” Biosensors 11, 295 (2021) (26pp).
  • W.-Z. Zhuang, Y.-H. Lin, L.-J. Su, M.-S. Wu, H.-Y. Jeng, H.-C. Chang, Y.-H. Huang*, and T.-Y. Ling*, “Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications,” J. Biomed. Sci. 28, 1–38 (2021).
  • Y.-Y. Liu, B.-M. Chang, and H.-C. Chang*, “Nanodiamond-enabled biomedical imaging,” Nanomedicine 15, 1599–1616 (2020).
  • C. Bradac*, S. F. Lim, H.-C. Chang, and I. Aharonovich, “Optical nanoscale thermometry: from fundamental mechanisms to emerging practical applications,” Adv. Opt. Mater. 8, 2000183 (2020) (29pp).
  • S. Sotoma, F.-J. Hsieh, and H.-C. Chang*, “Biohybrid fluorescent nanodiamonds as dual-contrast markers for light and electron microscopies,” J. Chin. Chem. Soc. 65, 1136–1146 (2018).
  • S. Sotoma, C. P. Epperla, and H.-C. Chang*, “Diamond nanothermometry,” ChemNanoMat 4, 15–27 (2018).
  • Y. Y. Hui, W. W.-W. Hsiao, S. Haziza, M. Simonneau, F. Treussart*, and H.-C. Chang*, “Single particle tracking of fluorescent nanodiamonds in cells and organisms,” Curr. Opin. Solid State Mater. Sci. 21, 35–42 (2017).
  • W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
  • V. Vaijayanthimala, D. K. Lee, S. V. Kim, A. Yen, N. Tsai, D. Ho*, H.-C. Chang*, and O. Shenderova*, “Nanodiamond-mediated drug delivery and imaging: challenges and opportunities,” Expert Opin. Drug Deliv. 12, 735–749 (2015).
  • Y. Y. Hui* and H.-C. Chang*, “Recent developments and applications of nanodiamonds as versatile bioimaging agents,” J. Chin. Chem. Soc. 61, 67–76 (2014).
  • Y. Y. Hui*, C.-L. Cheng*, and H.-C. Chang*, “Nanodiamonds for optical bioimaging,” J. Phys. D: Appl. Phys. 43, 374021 (2010) (11pp).
  • C.-C. Wu, C.-C. Han, and H.-C. Chang*, “Applications of surface-functionalized diamond nanoparticles for mass-spectrometry-based proteomics,” J. Chin. Chem. Soc. 57, 583–594 (2010).
  • H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
  • V. Vaijayanthimala and H.-C. Chang*, “Functionalized fluorescent nanodiamonds for biomedical applications,” Nanomedicine 4, 47–55 (2009).
  • H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
  • W.-P. Peng, Y. Cai, and H.-C. Chang*, “Optical detection methods for mass spectrometry of macroions,” Mass Spectrom. Rev. 23, 443–465 (2004).
Book Chapters (13)
  • W. W.-W. Hsiao, T.-N. Le, and H.-C. Chang, “Applications of fluorescent nanodiamond in biology,” in Encyclopedia of Analytical Chemistry, ed. J.-R. Albani (Wiley, 2022), Chap. a9776.
  • C. P. Epperla, H.-H. Lin, and H.-C. Chang, “Nanodiamonds and their biological applications,” in Carbon Nanostructures for Bio-Medical Applications, eds. T. Da Ros, N. Martin, and J.-F. Nierengarten (RSC, 2021), 257–292.
  • Y. Y. Hui, O. Y. Chen, H.-C. Chang, and M.-C. Su, in 21st Century Nanoscience – A Handbook: Exotic Nanostructures and Quantum Systems (Volume Five), ed. K. D. Sattler (CRC Press, 2020), Chap. 26, 26-1–26-18.
  • W. W.-W. Hsiao, H.-H. Lin, and H.-C. Chang, “Diamond nanoparticles for drug delivery and monitoring,” in Carbon-Based Nanosensor Technology, Springer Series on Chemical Sensors and Biosensors, ed. C. Kranz (Springer, 2019), 17: 119–140.
  • B.-M. Chang, D. Ho, and H.-C. Chang, “Biomarkers and drug delivery applications,” in Nanodiamonds: Advanced Material Analysis, Properties and Applications, ed. J.-C. Arnault (Elsevier, 2017), Chap. 16, pp. 403–417.
  • Y. Y. Hui, C.-A. Cheng, O. Y. Chen, and H.-C. Chang, “Bioimaging and quantum sensing using NV centers in diamond nanoparticles,” in Carbon Nanoparticles and Nanostructures, Carbon Nanostructures, eds. N. Yang, X. Jiang, and D.-W. Pang (Springer, 2016), pp. 109–137.
  • W. W.-W. Hsiao, H.-H. Lin, F.-J. Hsieh, and H.-C. Chang, “Surface-modified nanodiamonds,” in Carbon Nanomaterials Sourcebook: Graphene, Fullerenes, Nanotubes, and Nanodiamonds, Vol. I, ed. K. D. Sattler (CRC Press, 2016), Chap. 22, pp. 517–533.
  • V. Vaijayanthimala, C. P. Epperla, and H.-C. Chang, “Nanodiamonds,” in Nanoparticles for Biotherapeutic Delivery, Vol. 2, eds. J. D. Ramsey and M. L. Forrest (Future Science, 2015), Chap. 11, pp. 30–42.
  • N. Mohan and H.-C. Chang, “Fluorescent nanodiamonds and their prospects in bioimaging,” in Optical Engineering of Diamond, eds. R. Mildren and J. Rabeau (Wiley, 2013), Chap. 13, pp. 445–471.
  • V. Vaijayanthimala, Y. Y. Hui, and H.-C. Chang, “Nanodiamonds for bioimaging and therapeutic applications,” in The Nanobiotechnology Handbook, ed. Y. Xie (CRC Press, 2012), Chap. 25, pp. 537–563.
  • W. K. Liu, A. Adnan, A. Kopacz, M. Hallikainen, D. Ho, R. Lam, J. Lee, T. Belytschko, G. Schatz, Y. Tzeng, Y.-J. Kim, S. Baik, M. K. Kim, T. Kim, J. Lee, E.-S. Hwang, S. Im, E. Osawa, A. Barnard, H.-C. Chang, and C.-C. Chang, “Design of nanodiamond based drug delivery patch for cancer therapeutics and imaging applications,” in Nanodiamonds: Applications in Biology and Nanoscale Medicine, ed. D. Ho (Springer, 2009), Chap. 12, pp. 249–284.
  • H.-C. Chang, “Development and use of fluorescent nanodiamonds as cellular markers,” in Nanodiamonds: Applications in Biology and Nanoscale Medicine, ed. D. Ho (Springer, 2009), Chap. 6, pp. 127–150.
  • C. Su, H.-C. Chang, J.-K. Wang, and J.-C. Lin, “Hydrogen chemistry on diamond surfaces: Adsorption, desorption, and vibrational spectroscopy,” in Handbook of Surfaces and Interfaces of Materials, Vol. 2, ed. H. S. Nalwa (Academic Press, 2001), Chap. 8, pp. 315–355. 
Conference Proceedings (7)
  • S. Sotoma*, F.-J. Hsieh, Y.-W. Chen, J. Chen, K. Wardhani, P.-C. Tsai, and H.-C. Chang*, “Characterization and applications of fluorescent nanodiamonds surface-coated with photo-crosslinked lipids,” Proc. SPIE 10547, 1054704 (2018) (8pp).
  • H.-C. Chang*, “Diamonds in space: A brief history and recent laboratory studies,” J. Phys. Conf. Ser. 728, 062004 (2016) (6pp).
  • T. Zhang, H. Cui, C.-Y. Fang, J. Jo, X. Yang, H.-C. Chang, and M. L. Forrest*, “In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds,” Proc. SPIE 8815, 881504 (2013) (9pp).
  • Y. Kuo, T.-Y. Hsu, Y.-C. Wu, J.-H. Hsu*, and H.-C. Chang*, “Fluorescence lifetime imaging microscopy of nanodiamonds in vivo,” Proc. SPIE 8635, 863503 (2013) (7pp).
  • X. L. Le, A.-M. Lepagnol-Bestel, M.-P. Adam, A. Thomas, G. Dantelle, C.-C. Chang, N. Mohan, H.-C. Chang, F. Treussart*, and M. Simonneau, “Fluorescent diamond nanoparticle as a probe of intracellular traffic in primary neurons in culture,” Proc. SPIE 8232, 823203 (2012) (6pp).
  • C.-C. Chang, B. Zhang, C.-Y. Li, C.-C. Hsieh, G. Duclos, F. Treussart, and H.-C. Chang*, “Exploring cytoplasmic dynamics in zebrafish yolk cells by single particle tracking of fluorescent nanodiamonds,” Proc. SPIE 8272, 827205 (2012) (8pp).
  • N. Mohan, B. Zhang, C.-C. Chang, L. Yang, C.-S. Chen, C.-Y. Fang, H.-H. Hsieh, C.-Y. Cho, Y.-C. Wu, J.-H. Weng, B.-c. Chung, and H.-C. Chang*, “Fluorescent nanodiamond − A novel nanomaterial for in vivo applications,” MRS Proc. 1362, 25−35 (2011).
Patents (21)
  • H.-C. Chang, Y. Y. Hui, and Y.-X. Tang (2024), “Detection system and a portable detection device,” US Patent Application US20230103404A1.
  • H.-C. Chang, Y. Y. Hui, H.-H. Lin, and O. Y. Chen (2024), “Detection method and system for detecting biological samples,” US Patent Application US20220120757A1.
  • H.-C. Chang, Y. Y. Hui, and Y.-X. Tang (2024), “檢測系統 (A detection system),” ROC Patent I832469.
  • H.-M. Huang, S.-C. Hsieh, Y.-C. Chang, J.-C. Yang, and H.-C. Chang (2024), “根管治療沖洗液,” ROC Patent I830453.
  • H.-C. Chang, J. J. Yu, and J.-H. Kuo (2022), “測溫式定量檢測裝置 (Thermometric quantitative detection device),” ROC Patent M635550.
  • H.-C. Chang, Y. Y. Hui, H.-H. Lin, and O. Y. Chen (2022), “用於檢測生物樣本的檢測方法及檢測系統 (Detection method and system for detecting biological samples),” ROC Patent I771198.
  • H.-C. Chang, F.-J. Hsieh, and Y.-W. Chen (2022), “Encapsulated functionalized diamond crystal,” US Patent 11,366,119.
  • H.-C. Chang, F.-J. Hsieh, and Y.-W. Chen (2021), “包覆式功能化鑽石晶體(Encapsulated functionalized diamond crystal),” ROC Patent I745593.
  • B.-M. Cheng, H.-C. Lu, J.-I. Lo, and H.-C. Chang (2021), “Fluorescent nitrogen-vacancy diamond sensing sheet, manufacturing method and uses thereof, sensor, and lithography apparatus,” US Patent 11,029,421.
  • B.-M. Cheng, J.-I. Lo, H.-C. Lu, and H.-C. Chang (2021), “螢光氮空缺鑽石感測片、其製造方法與使用方法、感應器、及微影設備 (Fluorescent nitrogen-vacancy diamond (FNVD) sensing sheet, manufacturing method and uses thereof, sensor, and lithography apparatus),” ROC Patent I733183.
  • C.-H. Chen, W.-P. Peng, M.-L. Chu, H.-C. Chang, and H.-C. Lin (2015), “Bioparticle ionization with pressure controlled discharge for mass spectrometry,” US Patent 8,963,075.
  • H.-C. Chang, W. Fann, and C.-C. Han (2012), “Luminescent diamond particles,” US Patent 8,168,413. 
  • H.-C. Chang and C.-H. Chen (2010), “Acoustic desorption mass spectrometry,” US Patent 7,645,987. 
  • H.-C. Chang and C.-H. Chen (2008), “聲波脫附質譜儀 (Acoustic desorption mass spectrometry),” ROC Patent I292,822. 
  • C.-C. Han, H.-C. Chang, S.-C. Lee, and W.-H. Chen (2007), “Clinical applications of crystalline diamond particles,” US Patent 7,326,837. 
  • H.-C. Chang and C.-C. Han (2007), “鑽石微晶粒在生物科技上之應用 (Diamond crystallites for biotechnological applications),” ROC Patent I262,310.
  • H.-C. Chang and J. W. Ting (2007), “Biological whole cell mass spectrometer,” US Patent 7,161,147.  
  • H.-C. Chang, W.-P. Peng, and Y. Cai (2006), “探測奈米粒子之方法及其裝置 (Device of detecting nanoparticle and method of the same),” ROC Patent I257,705.
  • H.-C. Chang, W.-P. Peng, and Y. Cai (2006), “Nanoparticle ion detection,” US Patent 7,119,331.  
  • H.-C. Chang, W.-P. Peng, Y. Cai, and S.-J. Kuo (2006), “音頻離子阱單粒子質譜儀 (Audio-frequency single-particle ion trap mass spectrometer),” ROC Patent I250,278.
  • H.-C. Chang, W.-P. Peng, Y. Cai, and S.-J. Kuo (2004), “Ion trap mass spectrometer,” US Patent 6,777,673. 
 
目前位置：本所人員 / 研究人員 / 張煥正 / 全部研究成果
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最後更新於 2024-05-13 17:15:58
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