We are interested in the study of the guest-host interaction in the condensed phases, in particular the molecular recognition and the structural dynamics in biological systems. Specifically , we have introduced the satellite hole (SH) spectroscopy to the study of dye-DNA interaction during the last few years. R ecently, we have combined different optical method and bio-techniques to investigate the ligand-DNA binding structure and mechanism, particularly in t elomer es , for the anti-tumor drug development. Currently activates involve : |