張大釗
電子郵件 tcchang@po.iams.sinica.edu.tw
辦公室 232
辦公室電話 +886-2-2366-8231
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學歷
經歷
研究興趣
榮譽及獎項
代表作
  1. Tseng Ting-Yuan, Chu I-Te, Lin Shang-Jyun, Li Jie, Chang Ta-Chau*, 2019, “Binding of Small Molecules to G-quadruplex DNA in Cells Revealed by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci”, MOLECULES, 24(1):35. (SCI) (IF: 2.861; SCI ranking: 28.8%)
  2. Chu IT, Wu CC, Chang TC*, 2019, “G-quadruplex formation by single-base mutation or deletion of mitochondrial DNA sequences.”, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1863(2):418-425.
  3. Huang MC, Chu IT, Wang ZF, Lin S, Chang TC, Chen CT*, 2018, “A G-Quadruplex Structure in the Promoter Region of CLIC4 Functions as a Regulatory Element for Gene Expression.”, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(9):2678. (SCI) (IF: 3.226; SCI ranking: 40.3%,32.5%)
  4. Tseng TY, Chen WW, Chu IT, Wang CL, Chang CC, Lin MC, Lou PJ, Chang TC*, 2018, “The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers.”, SCIENTIFIC REPORTS, 8:16082. (SCI) (IF: 4.259; SCI ranking: 15.6%)
  5. Li Pei-Tzu, Wang Zi-Fu, Chu I-Te, Kuan Yen-Min, Li Ming-Hao, Huang Mu-Ching, Chiang Pei-Chi, Chang Ta-Chau*, Chen Chin-Tin*, 2017, “Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation”, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(51), 20859-20870. (SCI) (IF: 4.125; SCI ranking: 25.5%)
  6. Wang Zi-Fu, Li Ming-Hao, Chen Wei-Wen, Hsu Shang-Te Danny, Chang Ta-Chau*, 2016, “A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes”, NUCLEIC ACIDS RESEARCH, 44(8), 3958-3968. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  7. Chen Wei-Wen, Yi Yung-Hsiang, Chien Cheng-Hao, Hsiung Kuei-Ching, Ma Tian-Hsiang, Lin Yi-Chun, Lo Szecheng J., Chang Ta-Chau*, 2016, “Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging”, SCIENTIFIC REPORTS, 6(1), 32021-32033. (SCI) (IF: 4.259; SCI ranking: 15.6%)
  8. Yi-Chen Li, Jyh-Horng Wang, Li-Kai Tsai, Yun-An Chen, Ta-Chau Chang, Pei-Jen Lou*, Tai-Horng Young*, 2015, “ 3,6-Bis(1-methyl-4-vinylpyridinium)-carbazole diiodide as a marker for tracking living neural stem/precursor cells”, JOURNAL OF MATERIALS CHEMISTRY B, 3, 2067-2074. (SCI) (IF: 4.543; SCI ranking: 18.2%)
  9. TY Tseng, CC Chang, JJ Lin, TC Chang*, 2015, “A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth”, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 15(19), 1964-1970. (SCI) (IF: 2.864; SCI ranking: 38.3%)
  10. MH Kuo, ZF Wang, TY Tseng, MH Li, ST Hsu, JJ Lin, TC Chang*, 2015, “Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(1), 210-218. (SCI) (IF: 13.858; SCI ranking: 6%)
  11. WC Huang, TY Tseng, YT Chen, CC Chang, ZF Wang, CL Wang, TN Hsu, PT Li, CT Chen, JJ Lin, PJ Lou, TC Chang*, 2015, “Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents”, NUCLEIC ACIDS RESEARCH, 43(21), 10102-10113. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  12. IT Lin, YL Tsai, CC Kang, WC Huang, CL Wang, MY Lin, PJ Lou, JY Shih, HC Wang, HD Wu, TH Tsai, IS Jan*, TC Chang*, 2014, “BMVC test, an improved fluorescence assay for detection of malignant pleural effusions”, CANCER MEDICINE, 3(1), 162-173. (SCI) (IF: 3.362; SCI ranking: 41.5%)
  13. TL Yang*, L Lin, PJ Lou, TC Chang, TH Young*, 2014, “Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe”, PLOS ONE, 9(1), e86143. (SCI) (IF: 2.806; SCI ranking: 23.4%)
  14. JM Wang, FC Huang, MH Kuo, ZF Wang, TY Tseng, LC Chang, SJ Yen, TC Chang*, JJ Lin*, 2014, “Inhibition of Cancer Cell Migration and Invasion through Suppressing the Wnt1-mediating Signal Pathway by G-quadruplex Structure Stabilizers”, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 289(21), 14612-14623. (SCI) (IF: 4.125; SCI ranking: 25.5%)
  15. YH Yi, CH Chien, WW Chen, TH Ma, KY Liu, YS Chang, TC Chang, SJ Lo, 2014, “Lipid droplet pattern and nondroplet-like structure in two fat mutants of Caenorhabditis elegans revealed by coherent anti-Stokes Raman scattering microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 19(1), 011011. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
  16. ZF Wang, MH Li, ST Hsu, TC Chang*, 2014, “Structural basis of sodium-potassium exchange of a human telomeric DNA quadruplex without topological conversion”, NUCLEIC ACIDS RESEARCH, 42 (7), 4723-4733. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  17. MH Li, ZF Wang, MH Kuo, ST Hsu, TC Chang*, 2014, “Unfolding kinetics of human telomeric g-quadruplexes studied by NMR spectroscopy”, THE JOURNAL OF PHYSICAL CHEMISTRY B, 118(4), 931-936. (SCI) (IF: 3.177; SCI ranking: 33.6%)
  18. Pei-Chi Wei, Zi-Fu Wang, Wen-Ting Lo, Mei-I Su, Jin-Yuh Shew*, Ta-Chau Chang*, Wen-Hwa Lee*, 2013, “A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress”, NUCLEIC ACIDS RESEARCH, 41(3), 1533-1543. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  19. Meng-Chieh Hsieh, Cheng-Hao Chien, Cheng-Chung Chang*, Ta-Chau Chang, 2013, “Aggregation induced photodynamic therapy enhancement based on linear and nonlinear excited FRET of fluorescent organic nanoparticles”, JOURNAL OF MATERIALS CHEMISTRY B, 1, 2350-2357. (SCI) (IF: 4.543; SCI ranking: 18.2%)
  20. SW Liu, JF Chu, CT Tsai, HC Fang, TC Chang, HW Li, 2013, “Assaying the binding strength of G-quadruplex ligands using single-molecule TPM experiments”, ANALYTICAL BIOCHEMISTRY, 436(2), 101-108. (SCI) (IF: 2.334; SCI ranking: 44.7%,63.1%,56.4%)
  21. Wei-Wen Chen, Chen-Hao Chien, Chiung-Lin Wang, Huai-Hsien Wang, Yuh-Lin Wang, Shih-Torng Ding, Tzong-Shyuan Lee, Ta-Chau Chang* , 2013, “Automated quantitative analysis of lipid accumulation and hydrolysis in living macrophages with label-free imaging”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 405(26), 8549-8559. (SCI) (IF: 3.431; SCI ranking: 21.1%,33.3%)
  22. Chi-Chih Kang, Wei-Chun Huang, Chiung-Wen Kouh, Zi-Fu Wang, Chih-Chien Cho, Cheng-Chung Chang, Chiung-Lin Wang, Ta-Chau Chang*, Joachim Seemann, Lily Jun-shen Huang, 2013, “Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity”, INTEGRATIVE BIOLOGY, 5(10), 1217-1228. (SCI) (IF: 3.252; SCI ranking: 49.5%)
  23. Ting-Yuan Tseng, Cheng-Hao Chien, Jen-Fei Chu, Wei-Chun Huang, Mei-Ying Lin, Cheng-Chung Chang, Ta-Chau Chang*, 2013, “Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 18(10), 101309. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
  24. Ting-Yuan Tseng, Zi-Fu Wang, Cheng-Hao Chien, Ta-Chau Chang*, 2013, “In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands”, NUCLEIC ACIDS RESEARCH, 41(22), 10605-10618. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  25. Ya-Shuan Chou, Cheng-Chung Chang, Ta-Chau Chang, Tsung-Lin Yang, Tai-Horng Young, Pei-Jen Lou, 2013, “Photo-induced antitumor effect of 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide”, BIOMED RESEARCH INTERNATIONAL, 2013, 930281. (SCI) (IF: 2.476; SCI ranking: 41.9%,50.8%)
  26. Fon-Zuan Huang, Cheng-Chung Chang, Jing-Min Wang, Ta-Chau Chang*, Jing-Jer Lin*, 2012, “Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity”, BRITISH JOURNAL OF PHARMACOLOGY, 167(2), 393-406. (SCI) (IF: 5.491; SCI ranking: 7.4%)
  27. Cheng-Hao Chien, Wei-Wen Chen, June-Tai Wu, Ta-Chau Chang*, 2012, “Investigation of lipid homeostasis in living Drosophila by coherent anti-Stokes Raman scattering microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 17(12), 126001. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
  28. ZF Wang, TC Chang, 2012, “Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol”, NUCLEIC ACIDS RESEARCH, 40(17), 8711-20. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  29. Cheng-Chung Chang*, Meng-Chieh Hsieh, Jung-Chih Lin, Ta-Chau Chang, 2012, “Selective photodynamic therapy based on aggregation-induced emission enhancement of fluorescent organic nanoparticles”, BIOMATERIALS, 33(3), 897-906. (SCI) (IF: 8.402; SCI ranking: 3%,2.6%)
  30. Ta-Chau Chang*, Jen-Fei Chu, Yu-Lin Tsai, Zi-Fu Wang, 2012, “Structure conversion and structure separation of g-quadruplexes investigated by carbazole derivatives”, CURRENT PHARMACEUTICAL DESIGN, 18(14), 2002-2013. (SCI) (IF: 2.611; SCI ranking: 45.5%)
  31. Jen-Fei Chu, Zi-Fu Wang, Ting-Yuan Tseng, Ta-Chau Chang*, 2011, “A novel method for screening G-quadruplex stabilizers to human telomeres”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 58, 296-300. (SCI) (IF: 0.935; SCI ranking: 77.7%)
  32. Yu-Lin Tsai, Zi-Fu Wang, Wei-Wen Chen, Ta-Chau Chang*, 2011, “Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation”, NUCLEIC ACIDS RESEARCH, 39(17), e114. (SCI) (IF: 10.162; SCI ranking: 4.8%)
  33. Cheng-Hao Chien, Wei-Wen Chen, June-Tai Wu, Ta-Chau Chang*, 2011, “Label-free imaging of Drosophila in vivo by coherent anti-Stokes Raman scattering and two-photon excitation autofluorescence microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 16(1), 016012. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
  34. Chang-Tin Lin, Ting-Yuan Tseng, Zi-Fu Wang, Ta-Chau Chang*, 2011, “Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: the effect of potassium concentration and ion exchange”, JOURNAL OF PHYSICAL CHEMISTRY B, 115(10), 2360-70. (SCI) (IF: 3.177; SCI ranking: 33.6%)
  35. TC Chang, CC Chang, 2010, “Detection of G-quadruplexes in cells and investigation of G-quadruplex structure of d(T2AG3)4 in K+ solution by a carbazole derivative: BMVC”, METHODS IN MOLECULAR BIOLOGY, 608, 183-206.
  36. Jen-Fei Chu, Ta-Chau Chang, Hung-Wen Li*, 2010, “Single-molecule TPM studies on the conversion of human telomeric DNA”, BIOPHYSICAL JOURNAL, 98(8), 1608-16. (SCI) (IF: 3.656; SCI ranking: 23.3%)