Huan-Cheng Chang
Office 337
Tel. of office +886-2-2366-8260
Laboratory 510, NB11
Tel. of Lab. +886-2-2366-8226, +886-2-2366-8249
Research Interests
Honors, Awards, and Recognitions
Selected Publications
  1. H.-C. Chang, W. W.-W. Hsiao, and M.-C. Su, Fluorescent Nanodiamonds, Wiley (2019) (296pp).
  2. Y. Y. Hui, O. Y. Chen, H.-H. Lin, Y.-K. Su, K. Chen, C.-Y. Wang, W. W.-W. Hsiao, and H.-C. Chang*, “Magnetically modulated fluorescence of nitrogen-vacancy centers in nanodiamonds for ultrasensitive biomedical analysis,” Anal. Chem. 937140–7147 (2021).
  3. H.-C. Lu*, J.-I. Lo, Y.-C. Peng, S.-L. Chou, B.-M. Cheng*, and H.-C. Chang*, “Nitrogen-vacancy centers in diamond for high-performance detection of vacuum ultraviolet, extreme ultraviolet and X-rays,” ACS Appl. Mater. Interfaces 12, 3847−3853 (2020).
  4. F.-J. Hsieh, Y.-W. Chen, Y.-K. Huang, H.-M. Lee, C.-H. Lin, and H.-C. Chang*, “Correlative light-electron microscopy of lipid-encapsulated fluorescent nanodiamonds for nanometric localization of cell surface antigens,” Anal. Chem. 90, 1566–1571 (2018).
  5. H.-C. Lu*, S.-L. Chou, Y.-C. Peng, J.-I. Lo, B.-M. Cheng*, and H.-C. Chang*, “Far-UV excited luminescence of nitrogen-vacancy centers: Evidence for diamonds in space,” Angew. Chem. Int. Ed. 56, 14469–14473 (2017).
  6. L.-J. Su, M.-H. Wu, Y. Y. Hui, B.-M. Chang, L. Pan, P.-J. Hsu, Y.-T. Chen, H.-N. Ho, Y.-H. Huang, T.-Y. Ling*, H.-H. Hsu*, and H.-C. Chang*, “Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs,” Sci. Rep. 7, 45607 (2017) (11pp).  
  7. P.-C. Tsai, C. P. Epperla, J.-S. Huang, O. Y. Chen, C.-C. Wu, and H.-C. Chang*, “Measuring nanoscale thermostability of cell membranes with single gold-diamond nanohybrids,” Angew. Chem. Int. Ed. 56, 3025–3030 (2017).
  8. W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
  9. Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
  10. T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nat. Nanotechnol. 8, 682–689 (2013).
  11. V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012). 
  12. H.-C. Chang, W. Fann, and C.-C. Han, “Luminescent diamond particles,” US Patent 8,168,413 (2012). 
  13. Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
  14. N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
  15. H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
  16. Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nat. Nanotechnol. 3, 284–288 (2008).
  17. C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA 104, 727–732 (2007).
  18. Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
  19. S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
  20. X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259–265 (2005).
  21. H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
  22. L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir 20, 5879–5884 (2004).
  23. J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc. 122, 1398–1410 (2000).
  24. C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3712−3716 (1997).
  25. H.-C. Chang*, J.-C. Lin, J.-Y. Wu, and K.-H. Chen, “Infrared spectroscopy and vibrational relaxation of CHx and CDx stretches on synthetic diamond nanocrystal surfaces,” J. Phys. Chem. 99, 11081–11088 (1995).