Hsueh-Fen Juan

2025 – present Joint Appointment Research Fellow, The Institute of Atomic and Molecular Sciences (IAMS), Academia Sinica, Taiwan
2023 – present Deputy Vice President for Research and Development, NTU, Taiwan
2021 – present Director, Center for Computational and Systems Biology, NTU, Taiwan
2021 – present Adjunct Appointment Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes (NHRI), Taiwan
2020 – present Distinguished Professor, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics, Genome and Systems Biology Degree Program, Institute of Molecular and Cellular Biology, NTU, Taiwan
2017 –now Core Faculty, Bioinformatics Program, TIGP, Academia Sinica, Taiwan
2009 – 2020 Professor, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics, Genome and Systems Biology Degree Program, Institute of Molecular and Cellular Biology, NTU, Taiwan
2008 – 2009 Leader of Technology Service Group, Center for Biotechnology, NTU, Taiwan
2007 – 2008 Visiting Professor, Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, USA
2006 – 2009 Associate Professor, Department of Life Science, Institute of Molecular and Cellular Biology and Graduate Institute of Biomedical Electronics and Bioinformatics, NTU, Taiwan
2006 – 2007 Deputy Director, Center for Systems Biology and Bioinformatics, NTU, Taiwan
2006 – 2006 Visiting Professor, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
2004 – 2006 Assistant Professor, Department of Life Science & Institute of Molecular and Cellular Biology, NTU, Taiwan
2003 – 2004 Adjunct Assistant Professor, Department of Computer Science and Information Engineering, NTU, Taiwan
2002 – 2004 Assistant Professor, Institute of Chemical Engineering, National Taipei University of Technology, Taiwan
2001 – 2002 Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica, Taiwan
2001 – 2001 Research Associate, Japan International Research Center for Agricultural Sciences, Japan.
2000 – 2001 Research Assistant, Japan International Research Center for Agricultural Sciences, Japan

Artificial intelligence–driven drug development
Investigation of cell–cell communication
Single-cell multi-omics approaches to elucidate cellular dynamics
Relationship between mitochondrial energy proteins and cancer

2025 Outstanding Research Award from National Science and Technology Council (NSTC)
2025 Taiwan International Science and Engineering Fair (TISF) Advisor Prize
2024 Outstanding Teacher Service Award, NTU
2024 Advisor for College Student Research Creativity Award from National Science and Technology Council (NSTC)
2024 Taiwan International Science and Engineering Fair (TISF) Advisor Prize, and the high school student will go to International Swiss Talent Forum ISTF (Meeting with President Lai at the Presidential Office)
2021 Advisor for College Student Research Creativity Award from Ministry of Science and Technology (MOST)
2020 Fulbright Campus Advisor at National Taiwan University
2020 Outstanding Research Award from Ministry of Science and Technology (MOST)
2019 Advisor for College Student Research Creativity Award from Ministry of Science and Technology (MOST)
2015 Emerging Information and Technology Association (EITA) Service Award, USA
2012 K. T. Li Breakthrough Award by Institute of Information and Computing Machinery
2012 The Ph.D. Dissertation Advisor Award by Institute of Information and Computing Machinery
2012 Japan Society for the Promotion of Science (JSPS) Fellowship, Japan
2008 Taiwan's Ten Outstanding Young Persons
2007 National Science Council Foreign Short Term Research Fellowship
2006 Ministry of Education (MOE) Overseas Research Fellowship

Shih, J.-C.^#, Chen, P.-Y.^#, Kuo, C-.H., Hsieh, C.-H., Chang, H.-Y., Lee, H.-C., Huang, C.-H., Hsu, C.-H., Hsu, W.-M., Huang, H.-C.^*, Juan, H.-F.^* (2025). DHODH blockade induces ferroptosis in neuroblastoma by modulating the mevalonate pathway. Molecular and Cellular Proteomics 24(7):101014.
Juan, H.-F.^*and Huang, H.-C.^* (2023). Quantitative analysis of high-throughput biological data. WIREs Computational Molecular Science 13(4): e1658.
Kao, Y.-C., Chang, Y.-W., Lai, C. P., Chang, N.-W., Huang, C.-H., Huang, H.-C.^*, Juan, H.-F.^* (2023). Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells. Communications Biology 6:642
Chang, Y.-W., Yang, T.-T., Chen, M.-C., Liaw, Y.-G., Yin, C.-F., Huang, T.-Y., Hou, J.-T., Hung, Y.-H., Hsu C.-L., Huang, H.-C.^*, Juan, H.-F.^*(2023). Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface. Communications Biology 6:427.
Chen, K.-P., Hsu, C.-L., Oyang, Y.-J., Huang, H.-C.^*, Juan, H.-F.^* (2023). BIC: a database for the transcriptional landscape of bacteria in cancer. Nucleic Acids Research 51(D1):D1205-D1211.
Chang, Y.-W., Wang, C.-C, Yin, C.-F., Wu, C.-H., Huang, H.-C.^*, Juan, H.-F.^* (2022). Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK/c-Fos pathway activation. Molecular & Cellular Proteomics 21(6):100237.
Chen, T.-F., Chang, Y.-C., Hsiao, Y., Lee, K.-H., Hsiao, Y.-C., Lin, Y.-H., Tu, Y.-C. E., Huang, H.-C., Chen, C.-Y.^*, Juan, H.-F.^* (2021). DockCoV2: a drug database against SARS-CoV-2. Nucleic Acids Research 49(D1):D1152-D1159.
Chang, Y.-W., Hsu, C.-L., Tang, C.-W., Chen, X.-J., Huang, H.-C.^*, Juan, H.-F.^*(2020). Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network. Molecular and Cellular Proteomics 19(11):1805-1825.
Cheung, H. Y. C., Hsu, C.-L., Tsuei, C.-Y., Kuo, T.-T., Huang, C.-T., Hsu, W.-M., Chung, Y.-H., Wu, H.-Y., Hsu, C.-C., Huang, H.-C.^*, Juan, H.-F.^*(2019). Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. Cell Death & Disease 10:786.
Huang, C.-T., Hsieh, C.-H., Lee, W.-C., Liu, Y.-L., Yang, T.-S., Hsu, W.-M., Oyang, Y.-J., Huang, H.-C.^*, Juan, H.-F.^*(2019). Therapeutic targeting of non-oncogene dependencies in high-risk neuroblastoma. Clinical Cancer Research 25(13):4063-4078.