E-mail laicharles@sinica.edu.tw Office R204 Tel. of office 02-23668204 Laboratory L408 Tel. of Lab. 02-23668244
Education
Ph.D., 2010, University of British Columbia, Canada
B.S., 2003, University of British Columbia, Canada
Experience
2025-present Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica
2022-present Adjunct Associate Professor, Genome and Systems Biology Degree Program, National Taiwan University
2021-2025 Associate Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica
2017-2021 Assistant Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica
2018-2022 Adjunct Assistant Professor, Genome and Systems Biology Degree Program, National Taiwan University
2015-2017 Assistant Professor, Institute of Biomedical Engineering, National Tsing Hua University
2015-2015 Visiting Scholar, Institute of Atomic and Molecular Sciences, Academia Sinica
2014-2015 Instructor, Neuroscience Program, Harvard Medical School
2014-2015 Assistant in Neuroscience, Department of Neurology, Massachusetts General Hospital
2010-2014 Postdoctoral Fellow/Research Fellow, Neuroscience Program, Harvard Medical School
Research Interests
Molecular Bioimaging
Cell-to-Cell Communication
Genetic Engineering
Nanobiotechnology
Honors, Awards, and Recognitions
2024 Outstanding Research Award, National Science and Technology Council, Taiwan
2022-25 International Outstanding Young Scholars Research Grant, Ministry of Sciences and Technology, Taiwan
2022 Young Scholar Innovation Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan
2021 Young Scientist Award, YungShin Tien Te Lee Biomedical Foundation, Taiwan
2020-24 Career Development Award, Academia Sinica, Taiwan
2020-22 Outstanding Young Scholar Research Grant, Ministry of Science and Technology, Taiwan
2017-19 Academia Sinica Salary Bonus for Outstanding Faculties and Scholars, Academia Sinica, Taiwan
2015-17 Salary Bonus for Recruitment of Outstanding Faculties and Scholars, Ministry of Science and Technology, Taiwan
2015 Partners in Excellence (Teamwork), Massachusetts General Hospital, USA
2013 Excellence in Research, American Society for Gene and Cell Therapy, USA
2013 Travel Award, American Society for Gene and Cell Therapy, USA
2013 Young Investigator Award, International Society for Extracellular Vesicles, USA
2011-2014 Postdoctoral Fellowship, Canadian Institute of Health Research (CIHR), Canada
Selected Publications
Magoling, B., Chen,Y., Wu, A.Y., Wong, W.W., Chou, S.T., Huang, H., Sung, Y., Hsieh, H., Huang, P., Lee, K., Huang, K., Chen,R., Chen,Y., Lai, C.P.* (2023). Membrane protein modification modulates big and small extracellular vesicle biodistribution and tumorigenic potential in breast cancers in vivo. Advanced Materials. 35(13): e2208966.
Chien, J.C., Badr, C.E.*, Lai, C.P.* (2021). Multiplexed bioluminescence-mediated tracking of DNA double strand break repairs in vitro and in vivo. Nature Protocols. 16, 3933-3953. *Co-last authors.
Wu, A.Y., Sung, Y., Chen, Y., Chou, S.T., Guo, V., Chien, J.C., Ko, J.J., Yang, A.L., Huang, H., Chuang, J., Wu, S., Ho, M., Ericsson, M., Lin, W., Cheung, C.H.Y., Juan, H., Ueda, K., Chen, Y., Lai, C.P. (2020). Multiresolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism. Advanced Science. 7 (19): 2001467-83.
Chien J.C., Pinkham, K., da Hora, C.C., Tabet E., Badr C.E.*, Lai, C.P.*(2020). Multiplexed bioluminescent reporter enables real-time tracking of DNA double strand break repair dynamics in vitro and in vivo. Nucleic Acids Research.48 (17): e100-117. *Co-last authors.
Reátegui, E.,* van der Vos, K.E.,* Lai, C.P.,* Zeinali, M., Atai, N.A., Aldikacti, B., Floyd Jr., F.P., Khankhel, A.H., Thapar, V., Hochberg, F.H., Sequist, L.V., Nahed, B.V., Carter, B.S., Toner, M., Balaj, L., Ting, D.T., Breakefield, X.O., Stott, S.L. (2018). Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Nature Communications, 9 (1): 175-186.
Pucci, F., Garris, C., Lai, C.P., Newton, A., Pfirschke, C., Engblom, C., Alvarez, D., Sprachman, M., Evavold, C., Magnuson, A., von Andrian, U.H., Glatz, K., Breakefield, X.O., Mempel, T.R., Weissleder, R., Pittet, M.J. (2016). SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science, 352 (6282): 242-6.
Lai, C.P., Kim, K.Y., Badr, C.E., Mempel, T.R., Tannous, B.A., Breakefield, X.O. (2015). Visualization and tracking of tumor extracellular vesicles delivery and RNA translation using multiplexed reporters. Nature Communications, 6: 7029.1.
Zaborowski, M., Breakefield, X.O., Lai, C.P. (2015). Extracellular vesicles: composition, biological relevance and methods of study. Bioscience, 65 (8): 783-797.
Lai, C.P., Mardini, O., Ericsson, M., Prabhaker, S., Maguire A., Chen, J.W., Tannous, B.A., Breakefield, X.O. (2014). Dynamic biodistribution of extracellular vesicles in vivo using a multimodal reporter. ACS Nano, 8 (1): 483-94.
Lai, C.P., Bechberger, J., Naus, C. (2009). Pannexin2 as a Novel Negative Growth Regulator in C6 Gliomas. Oncogene, 28 (49): 4402-8.
Lai, C.P., Bechberger, J., Thompson, R.J., MacVicar, B., Bruzzone, R., Naus, C. (2007). Tumor-suppressive Effects of Pannexin1 in C6 Gliomas. Cancer Research, 67 (4): 1545-54.
