Chia-Lung Hsieh

E-mail clh@gate.sinica.edu.tw
Office R319
Tel. of office +886-2-2362-4956
Laboratory R321
Tel. of Lab. +886-2-2362-4955

B.S. , 2002, Electrical Engineering, National Tsing Hua University (NTHU), Taiwan
M.S., 2004, Electro-Optical Engineering, National Taiwan University (NTU), Taiwan
Ph.D., 2011, Electrical Engineering, California Institute of Technology, USA

2024 – Present Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan
2025 – Present Adjunct Professor, Department of Physics, National Taiwan University, Taiwan
2019 – 2024 Associate Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan
2022 – 2025 Adjunct Associate Professor, Department of Physics, National Taiwan University, Taiwan
2012 – 2019 Assistant Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan
2011 – 2012 Postdoctoral Research Fellow, Max Planck Institute for the Science of Light, Germany

Nanoscale biophysics
Quantitative bioanalytical approaches
Advanced optical microscopy
High-speed optical microscope techniques

2024 The 20th Tien Te Lee Young Investigator Award, Tien Te Lee Biomedical Foundation, Taiwan
2023 Outstanding Award, Chung Hwa Rotary Education Foundation, Taiwan
2022 The 20th Y. Z. Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, Taiwan
2021 The Ta-You Wu Memorial Award, Ministry of Science and Technology, Taiwan
2020 The Young Scholars' Creativity Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan
2019 Junior Research Investigator Award, Academia Sinica, Taiwan
2017 Career Development Award, Academia Sinica, Taiwan.

Cheng CY, Hsiao YT, Wong KL, Tseng HH, Tsao Y, Hsieh CL*, “Temporal variance mapping with machine learning for label-free 3D chromatin imaging using optical interferometric microscopy,” Biomedical Optics Express 17(2), pp. 527-543 (2026).
Tsai SF, Hsieh CL*, “Ultrasensitive bright-field microscope enables label-free single-protein detection,” Optics Letters, 50(24), pp.7520-7523 (2025).
Brooks NJ, Liu CC, Hsieh CL*, “Point spread function engineering for spiral phase interferometric scattering microscopy enables robust 3D single-particle tracking,” ACS Photonics 11(12), pp. 5239-5250 (2024).
Hsiao YT, Liao IH, Wu BK, Chu HP, Hsieh CL*, "Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy," Communications Biology 7: 763 (2024).
Hsiao YT, Tsai CN, Chen TH, Hsieh CL*, "Label-free dynamic imaging of chromatin in live cell nuclei by high-speed scattering-based interference microscopy," ACS Nano 16(2), 2774 (2022).
Huang YC, Chen TH, Juo JY, Chu SW, Hsieh CL*, "Quantitative imaging of single light-absorbing nanoparticles by widefield interferometric photothermal microscopy," ACS Photonics 8(2), 592 (2021).
Liao YH, Lin CH, Cheng CY, Wong WC, Juo JY, Hsieh CL*, "Monovalent and oriented labeling of gold nanoprobes for the high-resolution tracking of a single membrane molecule," ACS Nano 13(10), 10918 (2019).
Cheng CY, Liao YH, Hsieh CL*, "High-speed imaging and tracking of very small single nanoparticles by contrast enhanced microscopy," Nanoscale 11, 568 (2019).
Cheng CY, Hsieh CL*, "Background estimation and correction for high-precision localization microscopy," ACS Photonics 4(7), 1730 (2017).
Huang YF, Zhuo GY, Lin CH, Hsieh CL*, "Label-free, ultrahigh-speed, 3D observation of bidirectional and correlated intracellular cargo transport by coherent brightfield microscopy," Nanoscale 9 6567 (2017).
Huang YF, Zhuo GY, Chou CY, Lin CH, Chang W, Hsieh CL*, "Coherent brightfield microscopy provides the spatiotemporal resolution to study early stage viral infection in live cells," ACS Nano 11(3), 2575 (2017).