E-mail hchang@gate.sinica.edu.tw Office 337 Tel. of office +886-2-2366-8260 Laboratory 510, NB11 Tel. of Lab. +886-2-2366-8226, +886-2-2366-8249
Education
B. S., 1981, National Taiwan University, Taiwan
M. S., 1983, National Taiwan University, Taiwan
Ph. D., 1990, Indiana University at Bloomington, USA
Experience
1990–1993, Postdoctoral Fellow, Harvard University, USA
1994–1999, Associate Research Fellow, IAMS, Academia Sinica
1995–1996, Visiting Scientist, University of California at Berkeley, USA
2000–2013, Research Fellow, IAMS, Academia Sinica
2004–2009, Joint Appointment Professor, Department of Chemistry, National Taiwan Normal University
2005–2007, Panel Member, Division of Chemistry, National Science Council
2006–2013, Associate Editor, Journal of the Chinese Chemical Society, Taipei
2007–2012, Joint Appointment Professor, Department of Chemistry, National Taiwan University
2012–2016, Vice Executive Secretary, Central Academic Advisory Committee, Academia Sinica
2013–present, Distinguished Research Fellow, IAMS, Academia Sinica
2014–present, Honorary Chair Professor, Department of Chemical Engineering, National Taiwan University of Science and Technology
2016–present, Joint Appointment Professor, Department of Chemistry, National Taiwan Normal University
Research Interests
Biophysical Chemistry
Biomolecular Mass Spectrometry
Biophotonics
Nanobiotechnology
Honors, Awards, and Recognitions
1998, Academia Sinica Research Award for Junior Researchers
2001, Distinguished Young Researcher Award of Tsing-Hua Foundation of Chemistry Technology
2003–2005, National Science Council Outstanding Research Award
2007–2011, Academia Sinica Investigator Award
2007–2011, Outstanding Scholar Award of Foundation for the Advancement of Outstanding Scholarship
2008, Academic Award of Ministry of Education
2010–2013, Science Vanguard Research Program, National Science Council
2013–2017, Academia Sinica Investigator Award
2014–2017, Science Vanguard Research Program, Ministry of Science and Technology
2014, Best Article Award, Journal of the Chinese Chemical Society, Taipei
2014, Ho Chin Tui Award
2015–2017, Outstanding Research Award, Ministry of Science and Technology
2017, FutureTech Demo and Breakthrough Award, Ministry of Science and Technology
2017, Far Eastern Y. Z. Hsu Chair Professor
2019–2013, Academia Sinica Investigator Award
2019, The Franco-Taiwanese Scientific Grand Prize
2019, National Innovation Award of Taiwan Government
2019, Best Article Award, Journal of the Chinese Chemical Society, Taipei
2020, Outstanding Research Award, Taiwan Nanomedicine Society
2021, National Innovation Excelsior Award of Taiwan Government
2021, Academic Achievement Award, Chemical Society Located in Taipei
2023, FutureTech Award, National Science and Technology Council
Selected Publications
H.-C. Chang, W. W.-W. Hsiao, and M.-C. Su, Fluorescent Nanodiamonds, Wiley (2019) (296pp).
T.-I. Yang, Y.-Y. Hui, J.-I. Lo, Y.-W. Huang, Y.-Y. Lee, B.-M. Cheng*, and H.-C. Chang*, “Imaging extreme ultraviolet radiation using nanodiamonds with nitrogen-vacancy centers,” Nano Lett. 23, 9811–9816 (2023).
Y. Y. Hui, O. Y. Chen, H.-H. Lin, Y.-K. Su, K. Chen, C.-Y. Wang, W. W.-W. Hsiao, and H.-C. Chang*, “Magnetically modulated fluorescence of nitrogen-vacancy centers in nanodiamonds for ultrasensitive biomedical analysis,” Anal. Chem. 93, 7140–7147 (2021).
H.-C. Lu*, J.-I. Lo, Y.-C. Peng, S.-L. Chou, B.-M. Cheng*, and H.-C. Chang*, “Nitrogen-vacancy centers in diamond for high-performance detection of vacuum ultraviolet, extreme ultraviolet and X-rays,” ACS Appl. Mater. Interfaces12, 3847−3853 (2020).
F.-J. Hsieh, Y.-W. Chen, Y.-K. Huang, H.-M. Lee, C.-H. Lin, and H.-C. Chang*, “Correlative light-electron microscopy of lipid-encapsulated fluorescent nanodiamonds for nanometric localization of cell surface antigens,” Anal. Chem.90, 1566–1571 (2018).
H.-C. Lu*, S.-L. Chou, Y.-C. Peng, J.-I. Lo, B.-M. Cheng*, and H.-C. Chang*, “Far-UV excited luminescence of nitrogen-vacancy centers: Evidence for diamonds in space,” Angew. Chem. Int. Ed. 56, 14469–14473 (2017).
L.-J. Su, M.-H. Wu, Y. Y. Hui, B.-M. Chang, L. Pan, P.-J. Hsu, Y.-T. Chen, H.-N. Ho, Y.-H. Huang, T.-Y. Ling*, H.-H. Hsu*, and H.-C. Chang*, “Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs,” Sci. Rep.7, 45607 (2017) (11pp).
P.-C. Tsai, C. P. Epperla, J.-S. Huang, O. Y. Chen, C.-C. Wu, and H.-C. Chang*, “Measuring nanoscale thermostability of cell membranes with single gold-diamond nanohybrids,” Angew. Chem. Int. Ed. 56, 3025–3030 (2017).
W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nat. Nanotechnol. 8, 682–689 (2013).
V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012).
H.-C. Chang, W. Fann, and C.-C. Han, “Luminescent diamond particles,” US Patent 8,168,413 (2012).
Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed.50, 2262–2265 (2011).
N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett.10, 3692–3699 (2010).
H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nat. Nanotechnol. 3, 284–288 (2008).
C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA104, 727–732 (2007).
Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem.77, 259–265 (2005).
H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir20, 5879–5884 (2004).
J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc.122, 1398–1410 (2000).
C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3712−3716 (1997).
H.-C. Chang*, J.-C. Lin, J.-Y. Wu, and K.-H. Chen, “Infrared spectroscopy and vibrational relaxation of CHx and CDx stretches on synthetic diamond nanocrystal surfaces,” J. Phys. Chem.99, 11081–11088 (1995).