B.S., Chung-Yuan University (1976)

M.S., Texas Tech University, USA (1980)

Ph.D., Iowa State University, USA (1985)

Visiting Fellow, CIRES, Colorado (1985-1986)

Postdoctoral Fellow, University of Illinois (1986–1988)

Associate Research Fellow, IAMS, Academia Sinica (1988–1996)

Research Fellow, IAMS, Academia Sinica (1996–)

Joint Appointment Research Fellow, Genomics Research Center, Academia Sinica (2004–)

Joint Appointment Professor, Biophotonics Engineering, National Yang-Ming University (2005–)

Guest-host interaction in the condensed phases, particularly the molecular recognition and the structural dynamics in biological systems

Design and synthesis of new compounds for antitumor agents and fluorescence biomarkers

Dye-DNA interaction and conformational changes of telomeric DNA structures

Structure-activity relationship of antitumor agents

Bioanalytical methods development for the studies of telomere and telomerase in cancer research

“Vibrational investigation of DODC cation for recognition of guanine dimeric hairpin quadruplex studied by satellite holes”, J.-Y. Cheng and T.-C. Chang et al., J. Phys. Chem. B 102, 5542 (1998).

“Satellite hole investigation of thrombin-aptamer recognition”, T.-C. Chang et al., ChemBioChem. 3, 197 (2000).  

“A fluorescent carbazole derivative: High sensitivity for quadruplex DNA”, C.-C. Chang and T.-C. Chang et al., Anal. Chem. 75, 6177 (2003). 

“Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative”, C.-C. Chang and T.-C. Chang et al., Anal. Chem. 76, 4490 (2004). 

“A novel carbazole derivative, BMVC: A potential antitumor agent and fluorescence marker of cancer cells”, C.-C. Chang and T.-C. Chang et al., Chem. Biodiv. 1, 1377 (2004).