M.S., National Taiwan University (1983)

Ph.D., Indiana University at Bloomington (1990)

Postdoctoral Fellow, Harvard University (1990–1993)

Associate Research Fellow, IAMS, Academia Sinica (1994–1999)

Research Fellow, IAMS, Academia Sinica (2000–)

Visiting Scientist, University of California at Berkeley (1995–1996)

Joint Appointment Professor, Department of Chemistry, National Taiwan Normal University (2004–)

Joint Appointment Research Fellow, Genomics Research Center, Academia Sinica (2004–)

Structure and proton transfer in charged water clusters

Diamond nanocrystals for astrophysical and biotechnological applications

Single biological whole cell mass spectrometry With optical detection methods

Fourier transform ion cyclotron resonance mass spectrometry for current genomics and proteomics research

"Optical detection methods for mass spectrometry of macroions", W.-P. Peng and H.-C. Chang et al., Mass Spectrom. Rev. 23, 443 (2004). 

"High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis", X. L. Kong and H.-C. Chang et al., Anal. Chem. 77, 259 (2005). 

"Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity", S.-J. Yu and M.-W. Kang et al., J. Am. Chem. Soc. 127, 17604 (2005). 

"Laser-induced acoustic desorption mass spectrometry of single bioparticles", W.-P. Peng and Y.-C. Yang et al., Angew. Chem. Int. Ed. 45, 1423 (2006). 

"Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap", Z. X. Nie and Y.-K. Tzeng et al., Angew. Chem. Int. Ed. 45, 8131 (2006).