M.S., National Taiwan University (1983)

Ph.D., Indiana University at Bloomington (1990)

Postdoctoral Fellow, Harvard University (1990–1993)

Associate Research Fellow, IAMS, Academia Sinica (1994–1999)

Research Fellow, IAMS, Academia Sinica (2000–)

Visiting Scientist, University of California at Berkeley (1995–1996)

Joint Appointment Professor, Department of Chemistry, National Taiwan Normal University (2004–)

Joint Appointment Research Fellow, Genomics Research Center, Academia Sinica (2004–)

Structure and proton transfer in charged water clusters

Diamond nanocrystals for astrophysical and biotechnological applications

Single biological whole cell mass spectrometry With optical detection methods

Fourier transform ion cyclotron resonance mass spectrometry for current genomics and proteomics research

"High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis," X.L. Kong, L.C.L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang, Anal. Chem. 77, 259-265 (2005).

"Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity," S.-J. Yu, M.-W. Kang, H.-C. Chang, K.-M. Chen, and Y.-C. Yu, J. Am. Chem. Soc. 127, 17604-17605 (2005).

"Laser-induced acoustic desorption mass spectrometry of single bioparticles," W.-P. Peng, Y.-C. Yang, M.-W. Kang, Y.-K. Tzeng, Z.X. Nie, H.-C. Chang, W. Chang, and C.-H. Chen, Angew. Chem. Int. Ed. 45, 1423-1426 (2006).

"Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap," Z. X. Nie, Y.-K. Tzeng, H.-C. Chang, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, Angew. Chem. Int. Ed. 45, 8131-8134 (2006).

"Characterization and application of single fluorescent nanodiamonds as cellular biomarkers," C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang, and W. Fann, Proc. Natl. Acad. Sci. USA 104, 727-732 (2007).

"Mass production and dynamic imaging of fluorescent nanodiamonds," Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang, and W. Fann, Nature Nanotech. 3, 284-288 (2008).